Mathieu Schaaf1, Fabien Huet2, Mariama Akodad3, Anne-Marie Gorce-Dupuy4, Jérôme Adda5, Jean-Christophe Macia5, Delphine Delseny5, Florence Leclercq5, Jean-Paul Cristol6, Gregory Marin7, Nathan Mewton8, François Roubille3. 1. Service d'explorations fonctionnelles cardiovasculaires, cardiology division, hôpital Louis-Pradel, CHU de Lyon, 69500 Bron, France. 2. Cardiology division, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 34090 Montpellier, France; Inserm U1046, PhyMedExp, University of Montpellier, CNRS UMR 9214, 34090 Montpellier, France. Electronic address: huetfabienmontp@gmail.com. 3. Cardiology division, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 34090 Montpellier, France; Inserm U1046, PhyMedExp, University of Montpellier, CNRS UMR 9214, 34090 Montpellier, France. 4. Biochemistry division, Montpellier University Hospital, 34295 Montpellier, France. 5. Cardiology division, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 34090 Montpellier, France. 6. Inserm U1046, PhyMedExp, University of Montpellier, CNRS UMR 9214, 34090 Montpellier, France; Biochemistry division, Montpellier University Hospital, 34295 Montpellier, France. 7. Department of Medical Information, Montpellier University Hospital, 34295 Montpellier, France. 8. Service d'explorations fonctionnelles cardiovasculaires, cardiology division, hôpital Louis-Pradel, CHU de Lyon, 69500 Bron, France; Cardiology Department, Clinical Investigation Centre, hôpital Louis-Pradel, CHU de Lyon, 69500 Bron, France.
Abstract
BACKGROUND: The link between hs-Tn and infarct size has already been proved in several articles. However few is known about the kinetic of the troponin and its link to the infarct characteristics, likewise MVO. Our primary objective was to study which hs-Tn characterizes the best infarction. METHODS AND RESULTS: We identified 29 consecutive STEMI patients to study. The kinetics of hs-TnT (Roche) and two different TnIs (hs-TnI from Abbott, s-TnI from Siemens) were evaluated for all patients. Area under curves (AUC), first peak (FP) and second peak (SP), for hs-TnT, were compared to IS and MVO size using contrast-enhanced cardiac magnetic resonance. For IS, statistically SP of hs-TnT presented the best correlation compared to other peak values [r=0.9 vs. 0.73 for FP hs-TnT; vs. 0.69 for hs-TnI; vs. 0.57 for s-TnI; respectively P<0.01, P<0.01, P<0.01]. For MVO size, statistically SP of hs-TnT presented the best correlation compared to other peak values [r=0.84 vs. 0.75 for FP hs-TnT; vs. 0.72 for hs-TnI; vs. 0.62 for s-TnI; respectively P=0.01, P<0.01, P<0.01]. The best AUC were archived by the hs-TnT (AUC=0.95) but there were no statistical differences when compared to other hs-Tn AUC. CONCLUSION: The SP of hs-TnT had the greatest level of correlation and therefore seems to be the best biological parameter to evaluate and characterize infarct size.
BACKGROUND: The link between hs-Tn and infarct size has already been proved in several articles. However few is known about the kinetic of the troponin and its link to the infarct characteristics, likewise MVO. Our primary objective was to study which hs-Tn characterizes the best infarction. METHODS AND RESULTS: We identified 29 consecutive STEMI patients to study. The kinetics of hs-TnT (Roche) and two different TnIs (hs-TnI from Abbott, s-TnI from Siemens) were evaluated for all patients. Area under curves (AUC), first peak (FP) and second peak (SP), for hs-TnT, were compared to IS and MVO size using contrast-enhanced cardiac magnetic resonance. For IS, statistically SP of hs-TnT presented the best correlation compared to other peak values [r=0.9 vs. 0.73 for FP hs-TnT; vs. 0.69 for hs-TnI; vs. 0.57 for s-TnI; respectively P<0.01, P<0.01, P<0.01]. For MVO size, statistically SP of hs-TnT presented the best correlation compared to other peak values [r=0.84 vs. 0.75 for FP hs-TnT; vs. 0.72 for hs-TnI; vs. 0.62 for s-TnI; respectively P=0.01, P<0.01, P<0.01]. The best AUC were archived by the hs-TnT (AUC=0.95) but there were no statistical differences when compared to other hs-Tn AUC. CONCLUSION: The SP of hs-TnT had the greatest level of correlation and therefore seems to be the best biological parameter to evaluate and characterize infarct size.
Authors: Tau S Hartikainen; Alina Goßling; Nils A Sörensen; Jonas Lehmacher; Johannes T Neumann; Stefan Blankenberg; Dirk Westermann Journal: Front Cardiovasc Med Date: 2022-01-31