Joseph F Hayes1, David Pj Osborn1, Andreas Lundin2, Christina Dalman2. 1. 1 Division of Psychiatry, University College London, London, UK. 2. 2 Epidemiology of Psychiatric Conditions, Substance Use, and Social Environment, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Abstract
BACKGROUND: There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation. AIM: The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure. METHODS: We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007-31 December 2016 ( n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years). RESULTS: Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1-4 years after treatment cessation. CONCLUSION: We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.
BACKGROUND: There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation. AIM: The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure. METHODS: We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007-31 December 2016 ( n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years). RESULTS: Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1-4 years after treatment cessation. CONCLUSION: We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.
Entities:
Keywords:
Relapse; antipsychotic medication; first episode psychosis; hospitalization
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