Malakeh Malekzadeh1, Shahrokh Abbasi-Rad2, Mohamad Shahgholi3, Parisa Naghdi4, Marzieh Sadat Hoseini4, Niloofar Ayoobi Yazdi5, Mohammad Bagher Shiran1, Hamidreza Saligheh Rad6. 1. Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 2. Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran; Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran. 3. Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran. 4. Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran. 5. Advanced Diagnostic and Interventional Radiology (ADIR) Research Center, Tehran University of Medical Sciences, Tehran, Iran. 6. Quantitative Medical Imaging Systems Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran; Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: h-salighehrad@tums.ac.ir.
Abstract
INTRODUCTION: Quantitative computed tomography (QCT) can supplement dual x-ray absorptiometry by enabling geometric and compartmental bone assessments. Whole-body spiral CT scanners are widely available and require a short scanning time of seconds, in contrast to peripheral QCT scanners, which require several minutes of scanning time. This study designed and evaluated the accuracy and precision of a homemade QCT calibration phantom using a whole-body spiral CT scanner. MATERIALS AND METHODS: The QCT calibration phantom consisted of K2HPO4 solutions as reference. The reference material with various concentrations of 0, 50, 100, 200, 400, 1000, and 1200 mg/cc of K2HPO4 in water were used. For designing the phantom, we used the ABAQUS software. RESULTS: The phantoms were used for performance assessment of QCT method through measurement of accuracy and precision errors, which were generally less than 5.1% for different concentrations. The correlation between CT numbers and concentration were close to one (R2 = 0.99). DISCUSSION: Because whole-body spiral CT scanners allow central bone densitometry, evaluating the accuracy and precision for the easy to use calibration phantom may improve the QCT bone densitometry test. CONCLUSION: This study provides practical directions for applying a homemade calibration phantom for bone mineral density quantification in QCT technique.
INTRODUCTION: Quantitative computed tomography (QCT) can supplement dual x-ray absorptiometry by enabling geometric and compartmental bone assessments. Whole-body spiral CT scanners are widely available and require a short scanning time of seconds, in contrast to peripheral QCT scanners, which require several minutes of scanning time. This study designed and evaluated the accuracy and precision of a homemade QCT calibration phantom using a whole-body spiral CT scanner. MATERIALS AND METHODS: The QCT calibration phantom consisted of K2HPO4 solutions as reference. The reference material with various concentrations of 0, 50, 100, 200, 400, 1000, and 1200 mg/cc of K2HPO4 in water were used. For designing the phantom, we used the ABAQUS software. RESULTS: The phantoms were used for performance assessment of QCT method through measurement of accuracy and precision errors, which were generally less than 5.1% for different concentrations. The correlation between CT numbers and concentration were close to one (R2 = 0.99). DISCUSSION: Because whole-body spiral CT scanners allow central bone densitometry, evaluating the accuracy and precision for the easy to use calibration phantom may improve the QCT bone densitometry test. CONCLUSION: This study provides practical directions for applying a homemade calibration phantom for bone mineral density quantification in QCT technique.
Authors: Nithin Manohar Rayudu; Michael Dieckmeyer; Maximilian T Löffler; Peter B Noël; Jan S Kirschke; Thomas Baum; Karupppasamy Subburaj Journal: Front Endocrinol (Lausanne) Date: 2021-01-19 Impact factor: 5.555
Authors: Nithin Manohar Rayudu; Karupppasamy Subburaj; Kai Mei; Michael Dieckmeyer; Jan S Kirschke; Peter B Noël; Thomas Baum Journal: Front Endocrinol (Lausanne) Date: 2020-07-28 Impact factor: 5.555
Authors: Vitali Koch; Nils Große Hokamp; Moritz H Albrecht; Leon D Gruenewald; Ibrahim Yel; Jan Borggrefe; Stefan Wesarg; Katrin Eichler; Iris Burck; Tatjana Gruber-Rouh; Lukas Lenga; Thomas J Vogl; Simon S Martin; Julian L Wichmann; Renate M Hammerstingl; Leona S Alizadeh; Christoph Mader; Nicole A Huizinga; Tommaso D'Angelo; Giorgio Ascenti; Silvio Mazziotti; Christian Booz Journal: Eur Radiol Exp Date: 2021-10-05