Literature DB >> 30775926

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride.

Patrick R Melvin1, Devin M Ferguson1, Sydonie D Schimler1, Douglas C Bland2, Melanie S Sanford1.   

Abstract

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.

Entities:  

Year:  2019        PMID: 30775926     DOI: 10.1021/acs.orglett.9b00054

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  δ-C-H Mono- and Dihalogenation of Alcohols.

Authors:  Alastair N Herron; Dongxin Liu; Guoqin Xia; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2020-01-30       Impact factor: 15.419

2.  Late-Stage Conversion of a Metabolically Labile Aryl Methyl Ether-Containing Natural Product to Fluoroalkyl Analogues.

Authors:  Jacob P Sorrentino; Brett R Ambler; Ryan A Altman
Journal:  J Org Chem       Date:  2020-03-27       Impact factor: 4.354

  2 in total

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