Literature DB >> 30773599

Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre.

Rama P Namuduri1, Timothy Yk Lim1, Philip Kl Yam1, Rene Gatsinga2, Soo Kim Lim-Tan3, Sung Hock Chew3, Mark Ja Koh4, Sorsiah Mansor3.   

Abstract

We retrospectively reviewed the clinical features, management and outcomes of patients diagnosed with basal cell carcinoma (BCC) of the vulva at the Gynaecological Cancer Centre, KK Women's and Children's Hospital, Singapore, between 1 January 2000 and 28 February 2014. Patients with vulvar BCC were identified from the cancer registry, and their medical records reviewed and analysed. A total of 11 patients with vulvar BCC were identified. Mean age at diagnosis was 63 (range 30-85) years. Ethnically, ten patients were Chinese and one was Malay. Average time from onset of symptoms to diagnosis was 13.8 (range 2-60) months. The most common presenting symptoms were lump and pruritus. All patients were managed surgically. Recurrence was noted in only one patient. Vulvar BCC, although rare, has an excellent prognosis when managed appropriately. Histological diagnosis of all persistent papules, plaques and pigmented lesions is important for early diagnosis. Copyright: © Singapore Medical Association.

Entities:  

Keywords:  basal cell carcinoma; neoplasm; vulvar

Mesh:

Year:  2019        PMID: 30773599      PMCID: PMC7911082          DOI: 10.11622/smedj.2019014

Source DB:  PubMed          Journal:  Singapore Med J        ISSN: 0037-5675            Impact factor:   1.858


  18 in total

1.  bcl-2 protein expression in aggressive and non-aggressive basal cell carcinomas.

Authors:  P K Ramdial; A Madaree; R Reddy; R Chetty
Journal:  J Cutan Pathol       Date:  2000-07       Impact factor: 1.587

2.  Aggressive basal cell carcinoma with pulmonary metastases.

Authors:  Sei-Ichiro Motegi; Atsushi Tamura; Shigefumi Tanaka; Kyoko Nagai; Osamu Ishikawa
Journal:  Eur J Dermatol       Date:  2006 Sep-Oct       Impact factor: 3.328

Review 3.  Metastatic basal cell carcinoma of the vulva.

Authors:  S E Winkelmann; A S Llorens
Journal:  Gynecol Oncol       Date:  1990-07       Impact factor: 5.482

4.  Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.

Authors:  Shelby C Peterson; Markus Eberl; Alicia N Vagnozzi; Abdelmadjid Belkadi; Natalia A Veniaminova; Monique E Verhaegen; Christopher K Bichakjian; Nicole L Ward; Andrzej A Dlugosz; Sunny Y Wong
Journal:  Cell Stem Cell       Date:  2015-04-02       Impact factor: 24.633

5.  Basal-cell carcinoma incidence and associated risk factors in U.S. women and men.

Authors:  Shaowei Wu; Jiali Han; Wen-Qing Li; Tricia Li; Abrar A Qureshi
Journal:  Am J Epidemiol       Date:  2013-07-04       Impact factor: 4.897

Review 6.  Basal cell carcinoma of the vulva: clinical features and treatment results in 28 patients.

Authors:  J L Benedet; D M Miller; T G Ehlen; M A Bertrand
Journal:  Obstet Gynecol       Date:  1997-11       Impact factor: 7.661

7.  Basal cell carcinoma of the vulva: a clinicopathologic study of 45 cases.

Authors:  R M Feakins; D G Lowe
Journal:  Int J Gynecol Pathol       Date:  1997-10       Impact factor: 2.762

8.  Evidence that dysregulated DNA mismatch repair characterizes human nonmelanoma skin cancer.

Authors:  L C Young; J Listgarten; M J Trotter; S E Andrew; V A Tron
Journal:  Br J Dermatol       Date:  2007-10-26       Impact factor: 9.302

9.  Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97.

Authors:  D Koh; H Wang; J Lee; K S Chia; H P Lee; C L Goh
Journal:  Br J Dermatol       Date:  2003-06       Impact factor: 9.302

Review 10.  Vulvar squamous cell carcinoma: guidelines for early diagnosis and treatment.

Authors:  Stephen K Tyring
Journal:  Am J Obstet Gynecol       Date:  2003-09       Impact factor: 8.661

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  6 in total

1.  Comment on: Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre.

Authors:  Vincenzo De Giorgi; Federica Scarfì; Alessia Gori; Pierandrea Maida; Luciana Trane; Flavia Silvestri; Federico Venturi; Piero Covarelli
Journal:  Singapore Med J       Date:  2020-03       Impact factor: 1.858

2.  Authors' reply.

Authors:  Rama P Namuduri; Timothy Yk Lim; Philip Kl Yam; Rene Gatsinga; Soo Kim Lim-Tan; Sung Hock Chew; Mark Ja Koh; Sorsiah Mansor
Journal:  Singapore Med J       Date:  2020-03       Impact factor: 1.858

3.  Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis.

Authors:  Xi Chen; Yulong Hou; Can Chen; Guan Jiang
Journal:  Front Oncol       Date:  2021-01-26       Impact factor: 6.244

4.  Giant basal cell carcinoma of the vulva successfully treated with Sonidegib.

Authors:  Elisa Camela; Alessia Villani; Massimiliano Scalvenzi; Claudia Costa
Journal:  Dermatol Ther       Date:  2022-07-27       Impact factor: 3.858

5.  Treatment of vulvar basal cell carcinoma with Slow-Mohs micrographic surgery A case report.

Authors:  Ali Asilian; Reza Moeine; Hossein Hafezi; Reza Shahriarirad
Journal:  Clin Case Rep       Date:  2022-10-13

6.  Vulvar malignancies: an interdisciplinary perspective.

Authors:  Christoph Wohlmuth; Iris Wohlmuth-Wieser
Journal:  J Dtsch Dermatol Ges       Date:  2019-12-12       Impact factor: 5.584

  6 in total

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