Kristine S Corkum1, Daniel S Rhee2, Q Eileen Wafford3, Isabelle Demeestere4, Roshni Dasgupta5, Reto Baertschiger6, Marcus M Malek7, Jennifer H Aldrink8, Todd E Heaton9, Brent R Weil10, Mary Beth Madonna11, Timothy B Lautz12. 1. Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. 2. Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA. 3. Galter Health Sciences Library, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 4. Research Laboratory in Human Reproduction, Université Libre de Bruxelles, (ULB), Brussels, Belgium. 5. Department of Surgery, Cincinnati Children's Medical Center. 6. Division of Pediatric Surgery, Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. 7. Division of Pediatric General and Thoracic Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. 8. Division of Pediatric Surgery, Nationwide Children's Hospital, Department of Surgery, The Ohio State University College of Medicine, Columbus, OH. 9. Division of Pediatric Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. 10. Department of Surgery, Boston Children's Hospital, Boston, MA. 11. Department of Surgery, Rush University Medical Center. 12. Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Electronic address: tlautz@luriechildrens.org.
Abstract
BACKGROUND/ PURPOSE: The purpose of this systematic review by the American Pediatric Surgical Cancer Committee was to summarize evidence from the current medical literature regarding fertility restoration and hormone replacement for female children and adolescents treated with gonadotoxic treatments. METHODS: Using PRISMA guidelines, questions were addressed by searching Medline, Cochrane, Embase Central and National clearing house databases using relevant search terms. Eligible studies included those that addressed ovarian tissue cryopreservation (OTC), oocyte harvest, ovarian transposition, and ovarian tissue auto-transplantation for females under the age of 20. Four reviewers independently screened studies for eligibility, extracted data and assessed the risk of bias. Study outcomes were summarized in a narrative synthesis. RESULTS: Two thousand two hundred seventy-six studies were identified by database search and manual review and 2185 were eliminated based on defined exclusion criteria. Ninety-one studies served as the basis for the systematic review. There were 1019 patients who underwent OTC with ages ranging from 0.4 to 20.4 years old, with 298 under the age of 13. Twenty patients aged 13-20 years old underwent successful oocyte harvest. Thirty-seven children underwent ovarian transposition as a means of fertility preservation. Eighteen patients underwent auto-transplantation of thawed ovarian cortical tissue that was harvested before the age of 21 years resulting in 10 live births. CONCLUSIONS: Clinically accepted and experimental fertility preservation options such as OTC, oocyte cryopreservation, and ovarian transposition are available to females aged 20 years and younger who are at risk for premature ovarian insufficiency and infertility due to gonadotoxic treatments. There is a large cohort of pediatric-aged patients, with a wide variety of diagnoses and treatments, who have undergone fertility preservation. Currently, fertility and hormone restoration experience for patients who were 20- years of age or younger at the time of fertility preservation remains limited. LEVEL OF EVIDENCE: IV.
BACKGROUND/ PURPOSE: The purpose of this systematic review by the American Pediatric Surgical Cancer Committee was to summarize evidence from the current medical literature regarding fertility restoration and hormone replacement for female children and adolescents treated with gonadotoxic treatments. METHODS: Using PRISMA guidelines, questions were addressed by searching Medline, Cochrane, Embase Central and National clearing house databases using relevant search terms. Eligible studies included those that addressed ovarian tissue cryopreservation (OTC), oocyte harvest, ovarian transposition, and ovarian tissue auto-transplantation for females under the age of 20. Four reviewers independently screened studies for eligibility, extracted data and assessed the risk of bias. Study outcomes were summarized in a narrative synthesis. RESULTS: Two thousand two hundred seventy-six studies were identified by database search and manual review and 2185 were eliminated based on defined exclusion criteria. Ninety-one studies served as the basis for the systematic review. There were 1019 patients who underwent OTC with ages ranging from 0.4 to 20.4 years old, with 298 under the age of 13. Twenty patients aged 13-20 years old underwent successful oocyte harvest. Thirty-seven children underwent ovarian transposition as a means of fertility preservation. Eighteen patients underwent auto-transplantation of thawed ovarian cortical tissue that was harvested before the age of 21 years resulting in 10 live births. CONCLUSIONS: Clinically accepted and experimental fertility preservation options such as OTC, oocyte cryopreservation, and ovarian transposition are available to females aged 20 years and younger who are at risk for premature ovarian insufficiency and infertility due to gonadotoxic treatments. There is a large cohort of pediatric-aged patients, with a wide variety of diagnoses and treatments, who have undergone fertility preservation. Currently, fertility and hormone restoration experience for patients who were 20- years of age or younger at the time of fertility preservation remains limited. LEVEL OF EVIDENCE: IV.
Authors: Ashley A Diaz; Hana Kubo; Nicole Handa; Maria Hanna; Monica M Laronda Journal: Front Endocrinol (Lausanne) Date: 2022-06-10 Impact factor: 6.055
Authors: Rebecca A Clark; Sogol Mostoufi-Moab; Yutaka Yasui; Ngoc Khanh Vu; Charles A Sklar; Tarek Motan; Russell J Brooke; Todd M Gibson; Kevin C Oeffinger; Rebecca M Howell; Susan A Smith; Zhe Lu; Leslie L Robison; Wassim Chemaitilly; Melissa M Hudson; Gregory T Armstrong; Paul C Nathan; Yan Yuan Journal: Lancet Oncol Date: 2020-02-14 Impact factor: 41.316
Authors: Teresa K Woodruff; Lauren Ataman-Millhouse; Kelly S Acharya; Teresa Almeida-Santos; Antoinette Anazodo; Richard A Anderson; Leslie Appiah; Joy Bader; Kerri Becktell; Robert E Brannigan; Lesley Breech; Maria T Bourlon; Žana Bumbuliene; Karen Burns; Lisa Campo-Engelstein; Jacira R Campos; Grace M Centola; Mauricio Barbour Chehin; Diane Chen; Michel De Vos; Francesca E Duncan; Ahmed El-Damen; Douglas Fair; Yemi Famuyiwa; Patricia Y Fechner; Paula Fontoura; Olivia Frias; Sabrina A Gerkowicz; Jill Ginsberg; Clarisa R Gracia; Kara Goldman; Veronica Gomez-Lobo; Brent Hazelrigg; Michael H Hsieh; Luis R Hoyos; Alfonso Hoyos-Martinez; Robert Jach; Jacek Jassem; Murid Javed; Yasmin Jayasinghe; Roohi Jeelani; Jacqueline S Jeruss; Nalini Kaul-Mahajan; Jessica Keim-Malpass; Tyler G Ketterl; Mohamed Khrouf; Dana Kimelman; Atsuko Kusuhara; William H Kutteh; Monica M Laronda; Jung Ryeol Lee; Vicky Lehmann; Joseph M Letourneau; Lynda K McGinnis; Eileen McMahon; Lillian R Meacham; Monserrat Fabiola Velez Mijangos; Molly Moravek; Leena Nahata; George Moses Ogweno; Kyle E Orwig; Mary Ellen Pavone; Fedro Alessandro Peccatori; Romina Ileana Pesce; Hanna Pulaski; Gwendolyn Quinn; Ramiro Quintana; Tomas Quintana; Bruno Ramalho de Carvalho; Rosalind Ramsey-Goldman; Joyce Reinecke; Fernando M Reis; Julie Rios; Alice S Rhoton-Vlasak; Kenny A Rodriguez-Wallberg; Cassandra Roeca; Seth J Rotz; Erin Rowell; Mahmoud Salama; Amanda J Saraf; Anibal Scarella; Tara Schafer-Kalkhoff; Deb Schmidt; Suneeta Senapati; Divya Shah; Ariella Shikanov; Margarett Shnorhavorian; Jodi L Skiles; James F Smith; Kristin Smith; Fabio Sobral; Kyle Stimpert; H Irene Su; Kouhei Sugimoto; Nao Suzuki; Mili Thakur; David Victorson; Luz Viale; Wendy Vitek; W Hamish Wallace; Ellen A Wartella; Lynn M Westphal; Stacy Whiteside; Lea H Wilcox; Christine Wyns; Shuo Xiao; Jing Xu; Mary Zelinski Journal: J Assist Reprod Genet Date: 2021-01-06 Impact factor: 3.412
Authors: M E Madeleine van der Perk; Nicholas G Cost; Annelies M E Bos; Robert Brannigan; Tanzina Chowdhury; Andrew M Davidoff; Najat C Daw; Jeffrey S Dome; Peter Ehrlich; Norbert Graf; James Geller; John Kalapurakal; Kathleen Kieran; Marcus Malek; Mary F McAleer; Elizabeth Mullen; Luke Pater; Angela Polanco; Rodrigo Romao; Amanda F Saltzman; Amy L Walz; Andrew D Woods; Marry M van den Heuvel-Eibrink; Conrad V Fernandez Journal: Int J Cancer Date: 2022-05-11 Impact factor: 7.316