| Literature DB >> 30773387 |
Naomi A Fineberg1, Bernardo Dell'Osso2, Umberto Albert3, Giuseppe Maina4, Daniel Geller5, Lior Carmi6, Nick Sireau7, Susanne Walitza8, Giacomo Grassi9, Stefano Pallanti10, Eric Hollander11, Vlasios Brakoulias12, Jose M Menchon13, Donatella Marazziti14, Konstantinos Ioannidis15, Annemieke Apergis-Schoute16, Dan J Stein17, Danielle C Cath18, Dick J Veltman19, Michael Van Ameringen20, Leonardo F Fontenelle21, Roseli G Shavitt22, Daniel Costa22, Juliana B Diniz22, Joseph Zohar23.
Abstract
Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. The statement draws together evidence from epidemiological, clinical, health economic and brain imaging studies documenting the negative impact associated with treatment delay on clinical outcomes, and supporting the importance of early clinical intervention. It draws parallels between OCD and other disorders for which early intervention is recognized as beneficial, such as psychotic disorders and impulsive-compulsive disorders associated with problematic usage of the Internet, for which early intervention may prevent the development of later addictive disorders. It also generates new heuristics for exploring the brain-based mechanisms moderating the 'toxic' effect of an extended DUI in OCD. The statement concludes that there is a global unmet need for early intervention services for OC related disorders to reduce the unnecessary suffering and costly disability associated with under-treatment. New clinical staging models for OCD that may be used to facilitate primary, secondary and tertiary prevention within this context are proposed.Entities:
Keywords: Compulsive; Duration of untreated illness; Early intervention; OCD; Obsessive; Staging
Mesh:
Year: 2019 PMID: 30773387 DOI: 10.1016/j.euroneuro.2019.02.002
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN: 0924-977X Impact factor: 4.600