Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.

Literature DB >> 30772601

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.

D Bellavia¹, A De Luca², V Carina², V Costa², L Raimondi², F Salamanna³, R Alessandro⁴, M Fini³, G Giavaresi³.

Abstract

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.

Entities: Disease

Keywords: Osteoblast; Osteoclast; Osteogenesis; Osteoporosis; miRNA

Mesh：

Substances：
MicroRNAs

Year: 2019 PMID： 30772601 DOI： 10.1016/j.bone.2019.02.013

Source DB: PubMed Journal: Bone ISSN： 1873-2763 Impact factor: 4.398

Keyword Cloud
Cited

33 in total

1. Circulating MiR-21 expression is upregulated after 30 days of head-down tilt bed rest.

Authors: D A Bemben; B S Baker; S R Buchanan; C J Ade
Journal: Osteoporos Int Date: 2021-01-11 Impact factor: 4.507

2. Lnc90386 Sponges miR-33-5p to Mediate Mycoplasma gallisepticum-Induced Inflammation and Apoptosis in Chickens via the JNK Pathway.

Authors: Yingfei Sun; Yingjie Wang; Mengyun Zou; Tengfei Wang; Lulu Wang; Xiuli Peng
Journal: Front Immunol Date: 2022-06-27 Impact factor: 8.786

3. Circulating miRNAs associated with bone mineral density in healthy adult baboons.

Authors: Ellen E Quillen; Jaydee Foster; Anne Sheldrake; Maggie Stainback; Jeremy Glenn; Laura A Cox; Todd L Bredbenner
Journal: J Orthop Res Date: 2021-11-19 Impact factor: 3.102

Review 4. Recent advances in the epigenetics of bone metabolism.

Authors: Yuexin Xu; Jing Ma; Guohua Xu; Duan Ma
Journal: J Bone Miner Metab Date: 2021-07-11 Impact factor: 2.626

Review 5. The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease.

Authors: Christos Masaoutis; Stamatios Theocharis
Journal: Dis Markers Date: 2019-08-14 Impact factor: 3.434

Review 6. Perspectives on miRNAs as Epigenetic Markers in Osteoporosis and Bone Fracture Risk: A Step Forward in Personalized Diagnosis.

Authors: Michela Bottani; Giuseppe Banfi; Giovanni Lombardi
Journal: Front Genet Date: 2019-10-30 Impact factor: 4.599

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis.

1. Circulating MiR-21 expression is upregulated after 30 days of head-down tilt bed rest.

2. Lnc90386 Sponges miR-33-5p to Mediate Mycoplasma gallisepticum-Induced Inflammation and Apoptosis in Chickens via the JNK Pathway.

3. Circulating miRNAs associated with bone mineral density in healthy adult baboons.

Review 4. Recent advances in the epigenetics of bone metabolism.

Review 5. The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease.

Review 6. Perspectives on miRNAs as Epigenetic Markers in Osteoporosis and Bone Fracture Risk: A Step Forward in Personalized Diagnosis.

7. MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation.

8. Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR-29a-3p.

Review 9. Extracellular Vesicles: Potential Mediators of Psychosocial Stress Contribution to Osteoporosis?

10. miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.