E Meltzer1, G Smollan2, A Huppert3, R Fluss3, I Tal4, M Gilboa5, T Zilberman-Daniels6, N Keller7, G Rahav8, G Regev-Yochay9. 1. Infection Control & Prevention Unit, Sheba Medical Centre, Israel; Internal Medicine C, Sheba Medical Centre, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: emeltzer@post.tau.ac.il. 2. Microbiology Laboratory, Sheba Medical Centre, Israel. 3. Biostatistic Unit, Gertner Institute, Ramat Gan, Israel. 4. Infection Control & Prevention Unit, Sheba Medical Centre, Israel. 5. Internal Medicine D, Sheba Medical Centre, Israel. 6. Infectious Disease Unit, Sheba Medical Centre, Israel. 7. Microbiology Laboratory, Sheba Medical Centre, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 8. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Infectious Disease Unit, Sheba Medical Centre, Israel. 9. Infection Control & Prevention Unit, Sheba Medical Centre, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
OBJECTIVES: The role of asymptomatic carriers in Clostridioides difficile infection (CDI) epidemiology is not fully understood. Our aim was to evaluate CD carriage prevalence on admission, associated risk factors, and the risk of developing CDI. METHODS: A 10-week surveillance program for CD carriage of all medical patients admitted to the Sheba Medical Centre was implemented, utilizing an admission rectal swab PCR. Healthcare facility-onset CDI (HO-CDI) was recorded and divided into HO-CDI diagnosed in CD carriers and non-carriers. RESULTS: A total of 4601 admissions were recorded in 3803 patients; 2368 patients had technically analysable rectal swabs, of whom 81 (3.4%) were CD carriers. A multivariate logistic regression model showed that previous hospitalization, old age (>85 years) and low Norton scores were significant independent predictors of CD carriage. Carriers were more likely to receive antimicrobial therapy during hospitalization than non-carriers were. The incidence of HO-CDI in non-carriers was 4.6 cases per 10 000 patient-days; the incidence of HO-CDI in carriers was 76.7 cases per 10 000 patient-days (RR 16.6, 95% CI 4.0-69.1, p .002). CONCLUSIONS: In a prospective study, the rate of CD carriage on admission in medical patients was 3.4%. CD carriers were older, frailer, and more likely to have been hospitalized recently. HO-CDI incidence was significantly higher among CD carriers than among non-carriers, with at least a third of CDI in screened patients developing in carriers. Targeted screening of high-risk groups for CD carriage should be further considered.
OBJECTIVES: The role of asymptomatic carriers in Clostridioides difficile infection (CDI) epidemiology is not fully understood. Our aim was to evaluate CD carriage prevalence on admission, associated risk factors, and the risk of developing CDI. METHODS: A 10-week surveillance program for CD carriage of all medical patients admitted to the Sheba Medical Centre was implemented, utilizing an admission rectal swab PCR. Healthcare facility-onset CDI (HO-CDI) was recorded and divided into HO-CDI diagnosed in CD carriers and non-carriers. RESULTS: A total of 4601 admissions were recorded in 3803 patients; 2368 patients had technically analysable rectal swabs, of whom 81 (3.4%) were CD carriers. A multivariate logistic regression model showed that previous hospitalization, old age (>85 years) and low Norton scores were significant independent predictors of CD carriage. Carriers were more likely to receive antimicrobial therapy during hospitalization than non-carriers were. The incidence of HO-CDI in non-carriers was 4.6 cases per 10 000 patient-days; the incidence of HO-CDI in carriers was 76.7 cases per 10 000 patient-days (RR 16.6, 95% CI 4.0-69.1, p .002). CONCLUSIONS: In a prospective study, the rate of CD carriage on admission in medical patients was 3.4%. CD carriers were older, frailer, and more likely to have been hospitalized recently. HO-CDI incidence was significantly higher among CD carriers than among non-carriers, with at least a third of CDI in screened patients developing in carriers. Targeted screening of high-risk groups for CD carriage should be further considered.
Authors: Jay Worley; Mary L Delaney; Christopher K Cummins; Andrea DuBois; Michael Klompas; Lynn Bry Journal: Clin Infect Dis Date: 2021-10-05 Impact factor: 9.079
Authors: Kerrie Davies; Jody Lawrence; Claire Berry; Georgina Davis; Holly Yu; Bing Cai; Elisa Gonzalez; Ida Prantner; Andrea Kurcz; Ioana Macovei; Hanna Pituch; Elena Nováková; Otakar Nyč; Barbara Gärtner; Fabian K Berger; Monica Oleastro; Oliver A Cornely; Maria J G T Vehreschild; Louise Pedneault; Mark Wilcox Journal: Front Public Health Date: 2020-07-17