Literature DB >> 30771481

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review.

Giorgio Zenere1, Omalla Allan Olwenyi2, Siddappa N Byrareddy3, Stephen E Braun4.   

Abstract

Natural killer (NK) cells are innate immune lymphocytes with a key role in host defense against HIV infection. Recent advances in chimeric antigen receptors (CARs) have made NK cells a prime target for expressing recombinant receptors capable of redirecting NK cytotoxic functions towards HIV-infected cells. In this review, we discuss the role of NK cells in HIV and the mechanisms of actions of HIV-targeting CAR strategies. Furthermore, we also review NK cells signal transduction and its application to CAR NK cell strategies to develop new combinations of CAR intracellular domains and to improve CAR NK signaling and cytotoxic functions.
Copyright © 2019. Published by Elsevier Ltd.

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Year:  2019        PMID： 30771481      PMCID： PMC7065919          DOI： 10.1016/j.drudis.2019.02.002

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  86 in total

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Journal:  Mol Ther       Date:  2014-11-06       Impact factor: 11.454

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5.  Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation.

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  8 in total

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Authors:  Faroogh Marofi; Heshu Sulaiman Rahman; Lakshmi Thangavelu; Aleksey Dorofeev; Favian Bayas-Morejón; Naghmeh Shirafkan; Navid Shomali; Max Stanley Chartrand; Mostafa Jarahian; Ghasem Vahedi; Rebar N Mohammed; Somayeh Shahrokh; Morteza Akbari; Farhad Motavalli Khiavi
Journal:  Stem Cell Res Ther       Date:  2021-03-22       Impact factor: 6.832

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Review 4.  In-Vivo Induced CAR-T Cell for the Potential Breakthrough to Overcome the Barriers of Current CAR-T Cell Therapy.

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5.  DNAM-1-chimeric receptor-engineered NK cells, combined with Nutlin-3a, more effectively fight neuroblastoma cells in vitro: a proof-of-concept study.

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6.  Advances in HIV-1-specific chimeric antigen receptor cells to target the HIV-1 reservoir.

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  8 in total

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