Xenofon Baraliakos1,2, Florian Hoffmann3,4, Xiaohu Deng3,4, Yan-Yan Wang3,4, Feng Huang3,4, Juergen Braun3,4. 1. From the Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Herne, Germany; and the Department of Rheumatology, Chinese PLA General Hospital, Beijing, China. baraliakos@me.com. 2. X. Baraliakos, MD, Rheumazentrum Ruhrgebiet, Ruhr-University Bochum; F. Hoffmann, MD, Rheumazentrum Ruhrgebiet, Professor, Ruhr-University Bochum; X. Deng, MD, Department of Rheumatology, Chinese PLA General Hospital; Y. Wang, MD, Department of Rheumatology, Chinese PLA General Hospital; F. Huang, MD, Department of Rheumatology, Chinese PLA General Hospital; J. Braun, MD, Rheumazentrum Ruhrgebiet, Professor, Ruhr-University Bochum. baraliakos@me.com. 3. From the Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Herne, Germany; and the Department of Rheumatology, Chinese PLA General Hospital, Beijing, China. 4. X. Baraliakos, MD, Rheumazentrum Ruhrgebiet, Ruhr-University Bochum; F. Hoffmann, MD, Rheumazentrum Ruhrgebiet, Professor, Ruhr-University Bochum; X. Deng, MD, Department of Rheumatology, Chinese PLA General Hospital; Y. Wang, MD, Department of Rheumatology, Chinese PLA General Hospital; F. Huang, MD, Department of Rheumatology, Chinese PLA General Hospital; J. Braun, MD, Rheumazentrum Ruhrgebiet, Professor, Ruhr-University Bochum.
Abstract
OBJECTIVE: The volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) technique can visualize erosive cartilage defects in peripheral joints. We evaluated the ability of VIBE to detect erosions in sacroiliac joints (SIJ) of patients with axial spondyloarthritis (axSpA) compared to the established T1-weighted MRI sequence and computed tomography (CT). METHODS: MRI (T1-weighted and VIBE) and CT scans of SIJ of 109 patients with axSpA were evaluated by 2 blinded readers based on SIJ quadrants (SQ). Erosions were defined according to Assessment of Spondyloarthritis international Society (ASAS) definitions. Scores were recorded if readers were in agreement. RESULTS: Erosions were less frequently detected by CT (153 SQ) than by T1-weighted MRI (182 SQ; p = 0.008) and VIBE-MRI (199 SQ; p < 0.001 vs CT and p = 0.031 vs T1-weighted MRI). Taking CT as the gold standard, the sensitivity of VIBE-MRI (71.2%) was higher than that for T1-weighted MRI (63.4%), with similar specificity (87.3% vs 88%, respectively). In linear regression analysis, younger age was significantly associated with occurrence of erosions independently in VIBE-MRI (β = 0.384, p < 0.001) and T1-weighted MRI (β = 0.369, p < 0.001) compared to CT. CONCLUSION: The VIBE-MRI sequence was more sensitive than T1-weighted MRI in identifying erosive damage in the SIJ, especially in younger patients. This might be due to the ability of VIBE-MRI to identify structural changes in the cartilage that have not yet extended to the underlying bone, where CT seems to be superior.
OBJECTIVE: The volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) technique can visualize erosive cartilage defects in peripheral joints. We evaluated the ability of VIBE to detect erosions in sacroiliac joints (SIJ) of patients with axial spondyloarthritis (axSpA) compared to the established T1-weighted MRI sequence and computed tomography (CT). METHODS: MRI (T1-weighted and VIBE) and CT scans of SIJ of 109 patients with axSpA were evaluated by 2 blinded readers based on SIJ quadrants (SQ). Erosions were defined according to Assessment of Spondyloarthritis international Society (ASAS) definitions. Scores were recorded if readers were in agreement. RESULTS: Erosions were less frequently detected by CT (153 SQ) than by T1-weighted MRI (182 SQ; p = 0.008) and VIBE-MRI (199 SQ; p < 0.001 vs CT and p = 0.031 vs T1-weighted MRI). Taking CT as the gold standard, the sensitivity of VIBE-MRI (71.2%) was higher than that for T1-weighted MRI (63.4%), with similar specificity (87.3% vs 88%, respectively). In linear regression analysis, younger age was significantly associated with occurrence of erosions independently in VIBE-MRI (β = 0.384, p < 0.001) and T1-weighted MRI (β = 0.369, p < 0.001) compared to CT. CONCLUSION: The VIBE-MRI sequence was more sensitive than T1-weighted MRI in identifying erosive damage in the SIJ, especially in younger patients. This might be due to the ability of VIBE-MRI to identify structural changes in the cartilage that have not yet extended to the underlying bone, where CT seems to be superior.