Simon Krabbe1,2, Iris Eshed3,4, Frédérique Gandjbakhch3,4, Susanne J Pedersen3,4, Paul Bird3,4, Ashish J Mathew3,4, Robert G Lambert3,4, Walter P Maksymowych3,4, Daniel Glinatsi3,4, Maria S Stoenoiu3,4, René Poggenborg3,4, Lennart Jans3,4, Jacob L Jaremko3,4, Nele Herregods3,4, Violaine Foltz3,4, Philip G Conaghan3,4, Christian E Althoff3,4, Joel Paschke3,4, Charles Peterfy3,4, Kay-Geert A Hermann3,4, Mikkel Østergaard. 1. From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; University Pierre et Marie Curie - Paris 6, Sorbonne Universités, GRC-08 (EEMOIS); AP-HP, Rheumatology Department, Pitié Salpêtrière University Hospital, Paris, France; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India; Department of Radiology and Diagnostic Imaging, and Department of Medicine, University of Alberta; CaRE Arthritis, Edmonton, Canada; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels; Department of Radiology, Ghent University Hospital, Ghent, Belgium; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds Teaching Hospital National Health Service (NHS) Trust, UK; Department of Radiology, Arthritis Imaging Research Group, University Hospital Charité, Berlin, Germany; Spire Sciences Inc., Boca Raton, Florida, USA. simonkrabbe@gmail.com. 2. S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University; F. Gandjbakhch, MD, University Pierre et Marie Curie - Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Rheumatology Department, Pitié Salpêtrière University Hospital; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; P. Bird, MD, PhD, Division of Medicine, University of New South Wales; A.J. Mathew, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Clinical Immunology and Rheumatology, Christian Medical College; R.G. Lambert, MD, Department of Radiology and Diagnostic Imaging, University of Alberta; W.P. Maksymowych, MD, CaRE Arthritis, and Department of Medicine, University of Alberta; D. Glinatsi, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; M.S. Stoenoiu, MD, PhD, Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain; R. Poggenborg, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; L. Jans, MD, PhD, Department of Radiology, Ghent University Hospital; J.L. Jaremko, MD, PhD, Department of Radiology and Diagnostic Imaging, University of Alberta; N. Herregods, MD, PhD, Department of Radiology, Ghent University Hospital; V. Foltz, MD, University Pierre et Marie Curie - Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Rheumatology Department, Pitié Salpêtrière University Hospital; P.G. Conaghan, MD, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospital NHS Trust; C.E. Althoff, MD, Department of Radiology, Arthritis Imaging Research Group, University Hospital Charité; J. Paschke, BSc, CaRE Arthritis; C. Peterfy, MD, PhD, Spire Sciences Inc.; K.A. Hermann, MD, PhD, Department of Radiology, Arthritis Imaging Research Group, University Hospital Charité; M. Østergaard, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen. simonkrabbe@gmail.com. 3. From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; University Pierre et Marie Curie - Paris 6, Sorbonne Universités, GRC-08 (EEMOIS); AP-HP, Rheumatology Department, Pitié Salpêtrière University Hospital, Paris, France; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India; Department of Radiology and Diagnostic Imaging, and Department of Medicine, University of Alberta; CaRE Arthritis, Edmonton, Canada; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels; Department of Radiology, Ghent University Hospital, Ghent, Belgium; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds Teaching Hospital National Health Service (NHS) Trust, UK; Department of Radiology, Arthritis Imaging Research Group, University Hospital Charité, Berlin, Germany; Spire Sciences Inc., Boca Raton, Florida, USA. 4. S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University; F. Gandjbakhch, MD, University Pierre et Marie Curie - Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Rheumatology Department, Pitié Salpêtrière University Hospital; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; P. Bird, MD, PhD, Division of Medicine, University of New South Wales; A.J. Mathew, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Clinical Immunology and Rheumatology, Christian Medical College; R.G. Lambert, MD, Department of Radiology and Diagnostic Imaging, University of Alberta; W.P. Maksymowych, MD, CaRE Arthritis, and Department of Medicine, University of Alberta; D. Glinatsi, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; M.S. Stoenoiu, MD, PhD, Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain; R. Poggenborg, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; L. Jans, MD, PhD, Department of Radiology, Ghent University Hospital; J.L. Jaremko, MD, PhD, Department of Radiology and Diagnostic Imaging, University of Alberta; N. Herregods, MD, PhD, Department of Radiology, Ghent University Hospital; V. Foltz, MD, University Pierre et Marie Curie - Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Rheumatology Department, Pitié Salpêtrière University Hospital; P.G. Conaghan, MD, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospital NHS Trust; C.E. Althoff, MD, Department of Radiology, Arthritis Imaging Research Group, University Hospital Charité; J. Paschke, BSc, CaRE Arthritis; C. Peterfy, MD, PhD, Spire Sciences Inc.; K.A. Hermann, MD, PhD, Department of Radiology, Arthritis Imaging Research Group, University Hospital Charité; M. Østergaard, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen.
Abstract
OBJECTIVE: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis. METHODS: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis. RESULTS: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77. CONCLUSION: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
OBJECTIVE: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis. METHODS: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis. RESULTS: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77. CONCLUSION: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
Entities:
Keywords:
ARTHRITIS; MAGNETIC RESONANCE IMAGING; OMERACT; OUTCOME ASSESSMENT