Marco Garrido-Cumbrera1,2, C J Delgado-Domínguez3,4, D Gálvez-Ruiz3,4, C Blanch Mur3,4, V Navarro-Compán. 1. From Health & Territory Research of the Universidad de Sevilla, Seville; Spanish Federation of Spondyloarthritis Associations (CEADE), Madrid; Novartis, Spain; Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain. mcumbrera@us.es. 2. M. Garrido-Cumbrera, PhD, Health & Territory Research of the Universidad de Sevilla, and CEADE; C.J. Delgado-Domínguez, PhD, Health & Territory Research of the Universidad de Sevilla; D. Gálvez-Ruiz, PhD, Health & Territory Research of the Universidad de Sevilla; C. Blanch Mur, PhD, Novartis, Spain; V. Navarro-Compán, MD, PhD, IdiPAZ. mcumbrera@us.es. 3. From Health & Territory Research of the Universidad de Sevilla, Seville; Spanish Federation of Spondyloarthritis Associations (CEADE), Madrid; Novartis, Spain; Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain. 4. M. Garrido-Cumbrera, PhD, Health & Territory Research of the Universidad de Sevilla, and CEADE; C.J. Delgado-Domínguez, PhD, Health & Territory Research of the Universidad de Sevilla; D. Gálvez-Ruiz, PhD, Health & Territory Research of the Universidad de Sevilla; C. Blanch Mur, PhD, Novartis, Spain; V. Navarro-Compán, MD, PhD, IdiPAZ.
Abstract
OBJECTIVE: To assess the risk of mental disorders in patients with axial spondyloarthritis (axSpA) and to examine the factors associated with this. METHODS: In 2016, a sample of 680 patients with axSpA were interviewed as part of the development process for the Atlas of Axial Spondyloarthritis in Spain. The risk of mental disorders in these patients was assessed using the 12-item General Health Questionnaire scale. Additionally, the variables associated with the risk of mental disorders were investigated, including sociodemographic characteristics (age, sex, relationship, patient association membership, job status, and educational level), disease status (Bath Ankylosing Spondylitis Disease Activity Index, spinal stiffness, and functional limitation), and previous diagnosis of mental disorders (depression and anxiety). Bivariate correlation analyses were performed, followed by multiple hierarchical and stepwise regression analysis. RESULTS: A total of 45.6% patients were at risk of mental disorders. All variables except educational level and thoracic stiffness significantly correlated with risk of mental disorders. Nevertheless, disease activity, functional limitation, and age showed the highest coefficient (r = 0.543, p ≤ 0.001; r = 0.378, p ≤ 0.001; r = -0.174, p ≤ 0.001, respectively). In the stepwise regression analysis, 4 variables (disease activity, functional limitation, patient association membership, and cervical stiffness) explained the majority of the variance for the risk of mental disorders. Disease activity displayed the highest explanatory degree (R2 = 0.875, p < 0.001). CONCLUSION: In patients with axSpA, the prevalence of risk of mental disorders is high. Combined with a certain sociodemographic profile, high disease activity is a good indicator of the risk for mental disorders.
OBJECTIVE: To assess the risk of mental disorders in patients with axial spondyloarthritis (axSpA) and to examine the factors associated with this. METHODS: In 2016, a sample of 680 patients with axSpA were interviewed as part of the development process for the Atlas of Axial Spondyloarthritis in Spain. The risk of mental disorders in these patients was assessed using the 12-item General Health Questionnaire scale. Additionally, the variables associated with the risk of mental disorders were investigated, including sociodemographic characteristics (age, sex, relationship, patient association membership, job status, and educational level), disease status (Bath Ankylosing Spondylitis Disease Activity Index, spinal stiffness, and functional limitation), and previous diagnosis of mental disorders (depression and anxiety). Bivariate correlation analyses were performed, followed by multiple hierarchical and stepwise regression analysis. RESULTS: A total of 45.6% patients were at risk of mental disorders. All variables except educational level and thoracic stiffness significantly correlated with risk of mental disorders. Nevertheless, disease activity, functional limitation, and age showed the highest coefficient (r = 0.543, p ≤ 0.001; r = 0.378, p ≤ 0.001; r = -0.174, p ≤ 0.001, respectively). In the stepwise regression analysis, 4 variables (disease activity, functional limitation, patient association membership, and cervical stiffness) explained the majority of the variance for the risk of mental disorders. Disease activity displayed the highest explanatory degree (R2 = 0.875, p < 0.001). CONCLUSION: In patients with axSpA, the prevalence of risk of mental disorders is high. Combined with a certain sociodemographic profile, high disease activity is a good indicator of the risk for mental disorders.
Entities:
Keywords:
AXIAL SPONDYLOARTHRITIS; BASDAI; DEPRESSION; FUNCTIONAL LIMITATION; GENERAL HEALTH QUESTIONNAIRE; SPINAL STIFFNESS
Authors: Marco Garrido-Cumbrera; David Gálvez-Ruiz; Carlos J Delgado-Domínguez; Denis Poddubnyy; Victoria Navarro-Compán; Laura Christen; Raj Mahapatra; Souzi Makri; Christine Bundy Journal: RMD Open Date: 2021-11
Authors: Marco Garrido-Cumbrera; Christine Bundy; Victoria Navarro-Compán; Souzi Makri; Sergio Sanz-Gómez; Laura Christen; Raj Mahapatra; Carlos J Delgado-Domínguez; Denis Poddubnyy Journal: Arthritis Care Res (Hoboken) Date: 2021-12 Impact factor: 5.178