Literature DB >> 30770365

A PET Glutamate Analogue to Measure Cancer Cell Redox State and Oxidative Stress: Promise and Paradox.

Hsiaoju S Lee1, Austin R Pantel1, Rong Zhou1, David A Mankoff1.   

Abstract

[18F]FSPG was shown to provide an indirect measure of the cellular redox state and may be used as an early indicator of therapy response to cancer therapies that cause oxidative stress. A somewhat paradoxical finding was that reduced [18F]FSPG cellular uptake was associated with either lower cellular concentrations of cystine or glutamate, despite opposing the transport of these substances in the Xc- antiporter, for which [18F]FSPG is also a substrate. Further studies of the kinetics of [18F]FSPG will help elucidate the factors mediating a decline in [18F]FSPG with oxidative stress.See related article by McCormick et al, p. 853. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 30770365      PMCID： PMC6800034          DOI： 10.1158/0008-5472.CAN-18-4034

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  10 in total

1.  Specific PET imaging of xC- transporter activity using a ¹⁸F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism.

Authors:  Norman Koglin; Andre Mueller; Mathias Berndt; Heribert Schmitt-Willich; Luisella Toschi; Andrew W Stephens; Volker Gekeler; Matthias Friebe; Ludger M Dinkelborg
Journal:  Clin Cancer Res       Date:  2011-07-12       Impact factor: 12.531

2.  An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models.

Authors:  Aya Osanai-Sasakawa; Kenta Hosomi; Yoshiki Sumitomo; Takuya Takizawa; Shiho Tomura-Suruki; Minami Imaizumi; Noriyuki Kasai; Tze Wei Poh; Kazuya Yamano; Wei Peng Yong; Koji Kono; Satoshi Nakamura; Toshihiko Ishii; Ryuichiro Nakai
Journal:  Am J Cancer Res       Date:  2018-08-01       Impact factor: 6.166

3.  Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents.

Authors:  S Bannai
Journal:  J Biol Chem       Date:  1984-02-25       Impact factor: 5.157

4.  (4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies.

Authors:  Sora Baek; Andre Mueller; Young-Suk Lim; Han Chu Lee; Young-Joo Lee; Gyungyub Gong; Jae Seung Kim; Jin-Sook Ryu; Seung Jun Oh; Seung Jin Lee; Claudia Bacher-Stier; Lüder Fels; Norman Koglin; Christoph A Schatz; Ludger M Dinkelborg; Dae Hyuk Moon
Journal:  J Nucl Med       Date:  2012-12-11       Impact factor: 10.057

5.  The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo.

Authors:  Anant B Patel; Robin A de Graaf; Graeme F Mason; Douglas L Rothman; Robert G Shulman; Kevin L Behar
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-04       Impact factor: 11.205

6.  Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer.

Authors:  Sora Baek; Chang-Min Choi; Sei Hyun Ahn; Jong Won Lee; Gyungyub Gong; Jin-Sook Ryu; Seung Jun Oh; Claudia Bacher-Stier; Lüder Fels; Norman Koglin; Christina Hultsch; Christoph A Schatz; Ludger M Dinkelborg; Erik S Mittra; Sanjiv S Gambhir; Dae Hyuk Moon
Journal:  Clin Cancer Res       Date:  2012-08-14       Impact factor: 12.531

7.  [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition.

Authors:  Rong Zhou; Austin R Pantel; Shihong Li; Brian P Lieberman; Karl Ploessl; Hoon Choi; Eric Blankemeyer; Hsiaoju Lee; Hank F Kung; Robert H Mach; David A Mankoff
Journal:  Cancer Res       Date:  2017-02-15       Impact factor: 12.701

8.  Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc - Activity.

Authors:  Patrick N McCormick; Hannah E Greenwood; Matthias Glaser; Oliver D K Maddocks; Thibault Gendron; Kerstin Sander; Gayatri Gowrishankar; Aileen Hoehne; Tong Zhang; Adam J Shuhendler; David Y Lewis; Mathias Berndt; Norman Koglin; Mark F Lythgoe; Sanjiv S Gambhir; Erik Årstad; Timothy H Witney
Journal:  Cancer Res       Date:  2018-11-06       Impact factor: 12.701

Review 9.  Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth.

Authors:  Mariafrancesca Scalise; Lorena Pochini; Michele Galluccio; Lara Console; Cesare Indiveri
Journal:  Front Oncol       Date:  2017-12-11       Impact factor: 6.244

Review 10.  Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies.

Authors:  Austin R Pantel; Daniel Ackerman; Seung-Cheol Lee; David A Mankoff; Terence P Gade
Journal:  J Nucl Med       Date:  2018-07-24       Impact factor: 10.057
  10 in total

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