Antonis I Sakellarios1, Dimitrios I Fotiadis2. 1. Unit of Medical Technology and Intelligent Information Systems, University of Ioannina and Dept. of Biomedical Research, Institute of Molecular Biology and Biotechnology, Forth, GR 45110, Ioannina, Greece. Electronic address: ansakel13@gmail.com. 2. Unit of Medical Technology and Intelligent Information Systems, University of Ioannina and Dept. of Biomedical Research, Institute of Molecular Biology and Biotechnology, Forth, GR 45110, Ioannina, Greece.