Pragya Shrestha1, Rashmi Dhital2, Dilli Poudel3, Anthony Donato2, Paras Karmacharya4, Timothy Craig5. 1. Department of Internal Medicine, Reading Hospital-Tower Health System, West Reading, Pennsylvania. Electronic address: sh.pragya@gmail.com. 2. Department of Internal Medicine, Reading Hospital-Tower Health System, West Reading, Pennsylvania. 3. Department of Internal Medicine, Reading Hospital-Tower Health System, West Reading, Pennsylvania; Division of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. 4. Department of Internal Medicine, Reading Hospital-Tower Health System, West Reading, Pennsylvania; Division of Rheumatology, Mayo Clinic, Rochester, Minnesota. 5. Division of Pulmonary, Allergy, and Critical Care Medicine, Penn State College of Medicine, Hershey, Pennsylvania.
Abstract
BACKGROUND: Data on the prevalence of allergic disorders over time are limited. Recent studies have noted marked increase in the prevalence of allergic conditions in different parts of the world. OBJECTIVE: To examine time trends in the prevalence of anaphylaxis, angioedema, and urticaria in the United States. METHODS: Using the largest inpatient National Inpatient Sample data in the United States from 2001 to 2014, adults admitted with a primary diagnosis of anaphylaxis, angioedema, or urticaria were identified based on International Classification of Diseases, Ninth Revision codes. Yearly distribution of hospital admissions was stratified per different age groups, and yearly trends of hospitalizations related to anaphylaxis, angioedema, and urticaria were calculated. RESULTS: Although an increasing trend in the rate of hospitalizations was seen for angioedema (annual percentage change [APC], 4.48), a decreasing trend (APC, -2.19) was observed for urticaria-related hospitalizations. Overall anaphylaxis-related hospitalizations were noted to be stable, but a significant increasing trend was observed among those aged 5 to 14 years (APC, 4.19), mostly because of the subgroup of food-related hospitalizations (APC, 5.86). Angioedema-related hospitalizations were highest among the 35- to 64-year age group (APC, 5.38). CONCLUSION: An increasing trend of hospitalizations has been observed for allergic conditions, with varying age distribution according to the nature of eliciting agent and susceptibility of different age groups. Although angioedema has been observed as an increasing problem in older populations, food-induced anaphylaxis is an increasing concern in the younger population.
BACKGROUND: Data on the prevalence of allergic disorders over time are limited. Recent studies have noted marked increase in the prevalence of allergic conditions in different parts of the world. OBJECTIVE: To examine time trends in the prevalence of anaphylaxis, angioedema, and urticaria in the United States. METHODS: Using the largest inpatient National Inpatient Sample data in the United States from 2001 to 2014, adults admitted with a primary diagnosis of anaphylaxis, angioedema, or urticaria were identified based on International Classification of Diseases, Ninth Revision codes. Yearly distribution of hospital admissions was stratified per different age groups, and yearly trends of hospitalizations related to anaphylaxis, angioedema, and urticaria were calculated. RESULTS: Although an increasing trend in the rate of hospitalizations was seen for angioedema (annual percentage change [APC], 4.48), a decreasing trend (APC, -2.19) was observed for urticaria-related hospitalizations. Overall anaphylaxis-related hospitalizations were noted to be stable, but a significant increasing trend was observed among those aged 5 to 14 years (APC, 4.19), mostly because of the subgroup of food-related hospitalizations (APC, 5.86). Angioedema-related hospitalizations were highest among the 35- to 64-year age group (APC, 5.38). CONCLUSION: An increasing trend of hospitalizations has been observed for allergic conditions, with varying age distribution according to the nature of eliciting agent and susceptibility of different age groups. Although angioedema has been observed as an increasing problem in older populations, food-induced anaphylaxis is an increasing concern in the younger population.
Authors: Lacey B Robinson; Anna Chen Arroyo; Rebecca E Cash; Susan A Rudders; Carlos A Camargo Journal: Allergy Asthma Proc Date: 2021-05-01 Impact factor: 2.587
Authors: Anna Chen Arroyo; Lacey B Robinson; Rebecca E Cash; Mohammad Kamal Faridi; Kohei Hasegawa; Carlos A Camargo Journal: J Allergy Clin Immunol Pract Date: 2021-03-30
Authors: Lacey B Robinson; Anna Chen Arroyo; Mohammad Kamal Faridi; Susan A Rudders; Carlos A Camargo Journal: Ann Allergy Asthma Immunol Date: 2020-09-08 Impact factor: 6.347