Florence Boissier1,2,3, François Bagate1,4, Matthieu Schmidt5, Vincent Labbé6,7, Antoine Kimmoun8, Muriel Fartoukh6,7, Armand Mekontso Dessap1,4. 1. Service de Réanimation médicale, DHU A-TVB, Hôpital Henri Mondor, AP-HP, Créteil, France. 2. Service de Réanimation médicale, CHU de Poitiers, Poitiers, France. 3. INSERM CIC 1402 (ALIVE group), Université de Poitiers, Poitiers, France. 4. GRC CARMAS, IMRB, Faculté de Médecine de Créteil, Université Paris Est Créteil, Créteil, France. 5. Medical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre-et-Marie-Curie, Paris, France. 6. Service de Réanimation polyvalente, Hôpital Tenon, AP-HP, Paris, France. 7. UPMC Université Paris 6, Paris, France. 8. Service de Réanimation et Médecine Intensive Brabois, Institut Louis Mathieu, CHRU de Nancy, Vandoeuvre-les-Nancy, France.
Abstract
OBJECTIVES: Extracorporeal life support could be helpful for severe acute chest syndrome in adults sickle cell disease, because of the frequent hemodynamic compromise in this setting, including acute pulmonary vascular dysfunction and right ventricular failure. The aim of this study was to report the extracorporeal life support experience for severe acute chest syndrome in four referral centers in France. DESIGN: The primary endpoint of this multicentric retrospective study was ICU survival of patients with severe acute chest syndrome managed with extracorporeal life support. Secondary endpoints included comparisons between survivors and nonsurvivors. SETTING: We performed this study between January 2009 and July 2017 in four referral centers in France. PATIENTS: We included adult patients (age > 18 yr) with sickle cell disease, admitted for severe acute chest syndrome and who required extracorporeal life support during the ICU stay. INTERVENTIONS: The study was observational. MEASUREMENTS AND MAIN RESULTS: Over the 8-year period, 22 patients with sickle cell disease required extracorporeal life support for severe acute chest syndrome, including 10 (45%) veno-venous and 12 (55%) veno-arterial extracorporeal life support. In-ICU mortality was high (73%). Nonsurvivors had a higher severity at extracorporeal life support implantation, as assessed by their Vasoactive-Inotrope Score and number of organ failures. CONCLUSIONS: Our study shows that outcome is impaired in sickle cell disease patients receiving extracorporeal life support while in severe multiple organ failure. Further studies are needed to evaluate selection criteria in this setting.
OBJECTIVES: Extracorporeal life support could be helpful for severe acute chest syndrome in adults sickle cell disease, because of the frequent hemodynamic compromise in this setting, including acute pulmonary vascular dysfunction and right ventricular failure. The aim of this study was to report the extracorporeal life support experience for severe acute chest syndrome in four referral centers in France. DESIGN: The primary endpoint of this multicentric retrospective study was ICU survival of patients with severe acute chest syndrome managed with extracorporeal life support. Secondary endpoints included comparisons between survivors and nonsurvivors. SETTING: We performed this study between January 2009 and July 2017 in four referral centers in France. PATIENTS: We included adult patients (age > 18 yr) with sickle cell disease, admitted for severe acute chest syndrome and who required extracorporeal life support during the ICU stay. INTERVENTIONS: The study was observational. MEASUREMENTS AND MAIN RESULTS: Over the 8-year period, 22 patients with sickle cell disease required extracorporeal life support for severe acute chest syndrome, including 10 (45%) veno-venous and 12 (55%) veno-arterial extracorporeal life support. In-ICU mortality was high (73%). Nonsurvivors had a higher severity at extracorporeal life support implantation, as assessed by their Vasoactive-Inotrope Score and number of organ failures. CONCLUSIONS: Our study shows that outcome is impaired in sickle cell diseasepatients receiving extracorporeal life support while in severe multiple organ failure. Further studies are needed to evaluate selection criteria in this setting.