Literature DB >> 30767756

New Insights in Cannabinoid Receptor Structure and Signaling.

Lingyan Ye1, Zheng Cao1, Weiwei Wang1, Naiming Zhou1.   

Abstract

BACKGROUND: Cannabinoid has long been used for medicinal purposes. Cannabinoid signaling has been considered the therapeutic target for treating pain, addiction, obesity, inflammation, and other diseases. Recent studies have suggested that in addition to CB1 and CB2, there are non-CB1 and non-CB2 cannabinoid-related orphan GPCRs including GPR18, GPR55, and GPR119. In addition, CB1 and CB2 display allosteric binding and biased signaling, revealing correlations between biased signaling and functional outcomes. Interestingly, new investigations have indicated that CB1 is functionally present within the mitochondria of striated and heart muscles directly regulating intramitochondrial signaling and respiration.
CONCLUSION: In this review, we summarize the recent progress in cannabinoid-related orphan GPCRs, CB1/CB2 structure, Gi/Gs coupling, allosteric ligands and biased signaling, and mitochondria-localized CB1, and discuss the future promise of this research. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Cannabinoid receptor; allosteric ligand; biased signaling; mitochondria; orphan GPCRs; structure.

Mesh：

Substances：

Year:  2019        PMID： 30767756      PMCID： PMC6864585          DOI： 10.2174/1874467212666190215112036

Source DB:  PubMed          Journal:  Curr Mol Pharmacol        ISSN： 1874-4672            Impact factor:   3.339


  125 in total

1.  Allosteric modulation of the cannabinoid CB1 receptor.

Authors:  Martin R Price; Gemma L Baillie; Adèle Thomas; Lesley A Stevenson; Morag Easson; Richard Goodwin; Adèle McLean; Lorraine McIntosh; Gillian Goodwin; Glenn Walker; Paul Westwood; Julia Marrs; Fiona Thomson; Phillip Cowley; Arthur Christopoulos; Roger G Pertwee; Ruth A Ross
Journal:  Mol Pharmacol       Date:  2005-08-19       Impact factor: 4.436

2.  Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands.

Authors:  Brady K Atwood; James Wager-Miller; Christopher Haskins; Alex Straiker; Ken Mackie
Journal:  Mol Pharmacol       Date:  2011-11-07       Impact factor: 4.436

3.  Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis.

Authors:  Tiziano Tuccinardi; Pier Luigi Ferrarini; Clementina Manera; Gabriella Ortore; Giuseppe Saccomanni; Adriano Martinelli
Journal:  J Med Chem       Date:  2006-02-09       Impact factor: 7.446

Review 4.  Neuromodulatory functions of the endocannabinoid system.

Authors:  G Marsicano; B Lutz
Journal:  J Endocrinol Invest       Date:  2006       Impact factor: 4.256

Review 5.  Biased signalling in follicle stimulating hormone action.

Authors:  Flavie Landomiel; Nathalie Gallay; Gwenhael Jégot; Thibaud Tranchant; Guillaume Durand; Thomas Bourquard; Pascale Crépieux; Anne Poupon; Eric Reiter
Journal:  Mol Cell Endocrinol       Date:  2013-10-11       Impact factor: 4.102

6.  Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.

Authors:  M Sawzdargo; T Nguyen; D K Lee; K R Lynch; R Cheng; H H Heng; S R George; B F O'Dowd
Journal:  Brain Res Mol Brain Res       Date:  1999-02-05

7.  Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction.

Authors:  Saveria Aquila; Carmela Guido; Antonietta Santoro; Ida Perrotta; Chiara Laezza; Maurizio Bifulco; Andò Sebastiano
Journal:  Anat Rec (Hoboken)       Date:  2010-02       Impact factor: 2.064

8.  Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth.

Authors:  Shigeru Tanaka; Ken Ishii; Kazue Kasai; Sung Ok Yoon; Yoshinaga Saeki
Journal:  J Biol Chem       Date:  2007-02-06       Impact factor: 5.157

9.  Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.

Authors:  Evangelia Kotsikorou; Haleli Sharir; Derek M Shore; Dow P Hurst; Diane L Lynch; Karla E Madrigal; Susanne Heynen-Genel; Loribelle B Milan; Thomas D Y Chung; Herbert H Seltzman; Yushi Bai; Marc G Caron; Larry S Barak; Mitchell P Croatt; Mary E Abood; Patricia H Reggio
Journal:  Biochemistry       Date:  2013-12-17       Impact factor: 3.162

10.  GPCRdb: an information system for G protein-coupled receptors.

Authors:  Vignir Isberg; Stefan Mordalski; Christian Munk; Krzysztof Rataj; Kasper Harpsøe; Alexander S Hauser; Bas Vroling; Andrzej J Bojarski; Gert Vriend; David E Gloriam
Journal:  Nucleic Acids Res       Date:  2017-03-17       Impact factor: 16.971
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  23 in total

Review 1.  On the Biomedical Properties of Endocannabinoid Degradation and Reuptake Inhibitors: Pre-clinical and Clinical Evidence.

Authors:  Karen Jaqueline Paredes-Ruiz; Karla Chavira-Ramos; Mario Orozco-Morales; Cimen Karasu; Alexey A Tinkov; Michael Aschner; Abel Santamaría; Ana Laura Colín-González
Journal:  Neurotox Res       Date:  2021-11-06       Impact factor: 3.911

2.  Endocannabinoid-Binding Receptors as Drug Targets.

Authors:  María Gómez-Cañas; Carmen Rodríguez-Cueto; Valentina Satta; Inés Hernández-Fisac; Elisa Navarro; Javier Fernández-Ruiz
Journal:  Methods Mol Biol       Date:  2023

Review 3.  Chronic Pain and the Endocannabinoid System: Smart Lipids - A Novel Therapeutic Option?

Authors:  Walter Zieglgänsberger; Rudolf Brenneisen; Achim Berthele; Carsten T Wotjak; Borwin Bandelow; Thomas R Tölle; Beat Lutz
Journal:  Med Cannabis Cannabinoids       Date:  2022-03-22

Review 4.  Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases.

Authors:  Sebastián García; Virna Margarita Martín Giménez; Feres José Mocayar Marón; Russel J Reiter; Walter Manucha
Journal:  Histol Histopathol       Date:  2020-03-10       Impact factor: 2.303

5.  The impact of cannabinoid type 2 receptors (CB2Rs) in neuroprotection against neurological disorders.

Authors:  Qing Xin; Fei Xu; Devin H Taylor; Jing-Fu Zhao; Jie Wu
Journal:  Acta Pharmacol Sin       Date:  2020-10-06       Impact factor: 6.150

Review 6.  Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors.

Authors:  Srinagesh Mannekote Thippaiah; Sloka S Iyengar; K Yaragudri Vinod
Journal:  Front Psychiatry       Date:  2021-04-23       Impact factor: 4.157

Review 7.  Cannabidiol and periodontal inflammatory disease: A critical assessment.

Authors:  Petr Jirasek; Alexandr Jusku; Vilim Simanek; Jana Frankova; Jan Storch; Jan Vacek
Journal:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub       Date:  2022-03-21       Impact factor: 1.245

Review 8.  Advances in Neurobiology and Pharmacology of GPR12.

Authors:  Gonzalo Allende; Jesús Chávez-Reyes; Raquel Guerrero-Alba; Priscila Vázquez-León; Bruno A Marichal-Cancino
Journal:  Front Pharmacol       Date:  2020-05-08       Impact factor: 5.810

Review 9.  Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review.

Authors:  Marta Bryk; Katarzyna Starowicz
Journal:  Pharmacol Rep       Date:  2021-05-28       Impact factor: 3.024

Review 10.  Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival.

Authors:  Xinru Tang; Zheng Liu; Xiaoqing Li; Jing Wang; Liliang Li
Journal:  Int J Mol Sci       Date:  2021-06-26       Impact factor: 5.923
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