| Literature DB >> 30765607 |
Joel M Alves1,2,3, Miguel Carneiro4,5, Jade Y Cheng6,7, Ana Lemos de Matos8, Masmudur M Rahman8, Liisa Loog3,9, Paula F Campos7,10, Nathan Wales7,11,12, Anders Eriksson13, Andrea Manica14, Tanja Strive15,16, Stephen C Graham17, Sandra Afonso2, Diana J Bell18, Laura Belmont8, Jonathan P Day19, Susan J Fuller20, Stéphane Marchandeau21, William J Palmer22, Guillaume Queney23, Alison K Surridge18, Filipe G Vieira7, Grant McFadden8, Rasmus Nielsen6,7, M Thomas P Gilbert7,24, Pedro J Esteves2,25, Nuno Ferrand2,5,26, Francis M Jiggins1.
Abstract
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.Entities:
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Year: 2019 PMID： 30765607 PMCID： PMC6433279 DOI： 10.1126/science.aau7285
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728