Literature DB >> 30765567

How a circularized tmRNA moves through the ribosome.

Christopher D Rae1, Yuliya Gordiyenko1, V Ramakrishnan2.   

Abstract

During trans-translation, transfer-messenger RNA (tmRNA) and small protein B (SmpB) together rescue ribosomes stalled on a truncated mRNA and tag the nascent polypeptide for degradation. We used cryo-electron microscopy to determine the structures of three key states of the tmRNA-SmpB-ribosome complex during trans translation at resolutions of 3.7 to 4.4 angstroms. The results show how tmRNA and SmpB act specifically on stalled ribosomes and how the circularized complex moves through the ribosome, enabling translation to switch from the old defective message to the reading frame on tmRNA.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2019        PMID： 30765567      PMCID： PMC6440651          DOI： 10.1126/science.aav9370

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  SmpB, a unique RNA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA).

Authors:  A W Karzai; M M Susskind; R T Sauer
Journal:  EMBO J       Date:  1999-07-01       Impact factor: 11.598

2.  Determinants on tmRNA for initiating efficient and precise trans-translation: some mutations upstream of the tag-encoding sequence of Escherichia coli tmRNA shift the initiation point of trans-translation in vitro.

Authors:  S Lee; M Ishii; T Tadaki; A Muto; H Himeno
Journal:  RNA       Date:  2001-07       Impact factor: 4.942

3.  Functional evidence for D- and T-loop interactions in tmRNA.

Authors:  Sharief Barends; Karl Björk; Alexander P Gultyaev; Maarten H de Smit; Cornelis W A Pleij; Barend Kraal
Journal:  FEBS Lett       Date:  2002-03-06       Impact factor: 4.124

4.  The path of messenger RNA through the ribosome.

Authors:  G Z Yusupova; M M Yusupov; J H Cate; H F Noller
Journal:  Cell       Date:  2001-07-27       Impact factor: 41.582

5.  A third lineage with two-piece tmRNA.

Authors:  Stephen M Sharkady; Kelly P Williams
Journal:  Nucleic Acids Res       Date:  2004-08-23       Impact factor: 16.971

6.  Ribosome rescue by tmRNA requires truncated mRNAs.

Authors:  Natalia Ivanova; Michael Y Pavlov; Brice Felden; Måns Ehrenberg
Journal:  J Mol Biol       Date:  2004-04-16       Impact factor: 5.469

7.  A previously uncharacterized role for small protein B (SmpB) in transfer messenger RNA-mediated trans-translation.

Authors:  Thomas R Sundermeier; Daniel P Dulebohn; Hye Jin Cho; A Wali Karzai
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-07       Impact factor: 11.205

8.  Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli.

Authors:  Sean D Moore; Robert T Sauer
Journal:  Mol Microbiol       Date:  2005-10       Impact factor: 3.501

9.  Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA.

Authors:  Yoshitaka Bessho; Rie Shibata; Shun-ichi Sekine; Kazutaka Murayama; Kyoko Higashijima; Chie Hori-Takemoto; Mikako Shirouzu; Seiki Kuramitsu; Shigeyuki Yokoyama
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-08       Impact factor: 11.205

10.  A functional interaction of SmpB with tmRNA for determination of the resuming point of trans-translation.

Authors:  Takayuki Konno; Daisuke Kurita; Kazuma Takada; Akira Muto; Hyouta Himeno
Journal:  RNA       Date:  2007-08-13       Impact factor: 4.942
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  16 in total

1.  Primordial Protein Tails.

Authors:  Onn Brandman; Adam Frost
Journal:  Mol Cell       Date:  2021-01-07       Impact factor: 17.970

2.  Sequential rescue and repair of stalled and damaged ribosome by bacterial PrfH and RtcB.

Authors:  Yannan Tian; Fuxing Zeng; Adrika Raybarman; Shirin Fatma; Amy Carruthers; Qingrong Li; Raven H Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2022-07-12       Impact factor: 12.779

3.  Druggable differences: Targeting mechanistic differences between trans-translation and translation for selective antibiotic action.

Authors:  Pooja Srinivas; Kenneth C Keiler; Christine M Dunham
Journal:  Bioessays       Date:  2022-06-19       Impact factor: 4.653

Review 4.  Ribosome-associated quality-control mechanisms from bacteria to humans.

Authors:  Sebastian Filbeck; Federico Cerullo; Stefan Pfeffer; Claudio A P Joazeiro
Journal:  Mol Cell       Date:  2022-04-21       Impact factor: 19.328

5.  Diverse enzymatic activities mediate antiviral immunity in prokaryotes.

Authors:  Linyi Gao; Han Altae-Tran; Francisca Böhning; Kira S Makarova; Michael Segel; Jonathan L Schmid-Burgk; Jeremy Koob; Yuri I Wolf; Eugene V Koonin; Feng Zhang
Journal:  Science       Date:  2020-08-28       Impact factor: 47.728

6.  Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex.

Authors:  Robert S Washburn; Philipp K Zuber; Ming Sun; Yaser Hashem; Bingxin Shen; Wen Li; Sho Harvey; Francisco J Acosta Reyes; Max E Gottesman; Stefan H Knauer; Joachim Frank
Journal:  iScience       Date:  2020-07-09

7.  CryoEM at 100 keV: a demonstration and prospects.

Authors:  K Naydenova; G McMullan; M J Peet; Y Lee; P C Edwards; S Chen; E Leahy; S Scotcher; R Henderson; C J Russo
Journal:  IUCrJ       Date:  2019-10-11       Impact factor: 4.769

8.  Elongational stalling activates mitoribosome-associated quality control.

Authors:  Nirupa Desai; Hanting Yang; Viswanathan Chandrasekaran; Razina Kazi; Michal Minczuk; V Ramakrishnan
Journal:  Science       Date:  2020-11-27       Impact factor: 47.728

9.  Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach.

Authors:  Iskander Khusainov; Bulat Fatkhullin; Simone Pellegrino; Aydar Bikmullin; Wen-Ti Liu; Azat Gabdulkhakov; Amr Al Shebel; Alexander Golubev; Denis Zeyer; Natalie Trachtmann; Georg A Sprenger; Shamil Validov; Konstantin Usachev; Gulnara Yusupova; Marat Yusupov
Journal:  Nat Commun       Date:  2020-04-03       Impact factor: 14.919

10.  Quality controls induced by aberrant translation.

Authors:  Toshifumi Inada
Journal:  Nucleic Acids Res       Date:  2020-02-20       Impact factor: 16.971
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