C Vanhecke1, R Girerd2, M Dujardin2, N Zemali3, R Manaquin4, P Duport5, N Traversier6, K Mougin-Damour2, D Vandroux7. 1. Service des urgences-SMUR du centre hospitalier Gabriel Martin, 38, rue Labourdonnais CS 11045, 97166 Saint-Paul, Reunion; Centre René Labusquière, (Institut de Médecine tropicale), Université Victor Segalen, 33000 Bordeaux, France. 2. Service des urgences-SMUR du centre hospitalier Gabriel Martin, 38, rue Labourdonnais CS 11045, 97166 Saint-Paul, Reunion. 3. Laboratoire de microbiologie, centre hospitalier universitaire, site de Saint-Pierre, 97410 Saint-Pierre, Reunion. 4. Service de maladies infectieuses, centre hospitalier universitaire, site de Saint Pierre, 97410 Saint-Pierre, Reunion. 5. Service de réanimation pédiatrique, centre hospitalier universitaire, site Felix Guyon, allée des Topazes, CS11021, 97400 Saint-Denis, Reunion. 6. Laboratoire de microbiologie, centre hospitalier universitaire, site Felix Guyon, allée des Topazes, CS11021, 97400 Saint-Denis, Reunion. 7. Centre René Labusquière, (Institut de Médecine tropicale), Université Victor Segalen, 33000 Bordeaux, France; Service de réanimation polyvalente, centre hospitalier universitaire, site Felix Guyon, allée des Topazes, CS11021, 97400 Saint-Denis, Reunion.
Abstract
OBJECTIVE: Panton-Valentine leukocidin-producing Staphylococcus aureus necrotizing pneumonia is an unusual cause of community-acquired pneumonia, although associated with a high case fatality. This infection mainly affects young individuals, without any history, and is most often preceded by flu-like symptoms. METHOD: We focused on patients presenting with Staphylococcus aureus necrotizing pneumonia in Reunion (Indian Ocean) admitted to the emergency department. We performed a retrospective study based on data collected from laboratory registers and medical files of patients presenting with Staphylococcus aureus necrotizing pneumonia in Reunion between December 2014 and December 2017. RESULTS: A total of 16 patients were recruited for this study, with a median age of 40.5 years. More than half of patients had previously been admitted to the emergency department for acute respiratory distress syndrome or severe sepsis. Fourteen patients were admitted to the intensive care unit and six patients died (five premature deaths). CONCLUSION: Physicians should be aware of this infection during the flu season and quickly adapt the specific antibiotic treatment, including a drug inhibiting toxin production. As methicillin-resistant Staphylococcus aureus is very rarely observed in Reunion, physicians can still adapt the empirical treatment, without glycopeptides.
OBJECTIVE: Panton-Valentine leukocidin-producing Staphylococcus aureus necrotizing pneumonia is an unusual cause of community-acquired pneumonia, although associated with a high case fatality. This infection mainly affects young individuals, without any history, and is most often preceded by flu-like symptoms. METHOD: We focused on patients presenting with Staphylococcus aureus necrotizing pneumonia in Reunion (Indian Ocean) admitted to the emergency department. We performed a retrospective study based on data collected from laboratory registers and medical files of patients presenting with Staphylococcus aureus necrotizing pneumonia in Reunion between December 2014 and December 2017. RESULTS: A total of 16 patients were recruited for this study, with a median age of 40.5 years. More than half of patients had previously been admitted to the emergency department for acute respiratory distress syndrome or severe sepsis. Fourteen patients were admitted to the intensive care unit and six patientsdied (five premature deaths). CONCLUSION: Physicians should be aware of this infection during the flu season and quickly adapt the specific antibiotic treatment, including a drug inhibiting toxin production. As methicillin-resistant Staphylococcus aureus is very rarely observed in Reunion, physicians can still adapt the empirical treatment, without glycopeptides.
Authors: Letizia Capasso; Julia Cerullo; Andrea Lo Vecchio; Clara Coppola; Lorenza Lepore; Valentina Marra; Eleni Antonaki; Francesco Raimondi Journal: Acta Biomed Date: 2021-04-30