Minyoul Baik1, Seung Up Kim2,3, Sungwoo Kang1, Hyung Jong Park1, Hyo Suk Nam1, Ji Hoe Heo1, Beom Kyung Kim2,3, Jun Yong Park2,3, Do Young Kim2,3, Sang Hoon Ahn2,3, Kwang-Hyub Han2,3, Hye Sun Lee4, Young Dae Kim5. 1. Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea. 2. Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea. 3. Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea. 4. Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. 5. Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea, neuro05@yuhs.ac.
Abstract
BACKGROUND: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). - Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. RESULTS: Among 395 patients included in this study, there were 37 (9%) patients with significant fibrosis (> 8.0 kPa) and 164 (41.5%) patients with fatty liver (> 250 dB/m). During the follow-up period (median 2.7 years), all-cause and cardiovascular mortality occurred in 28 (7.1%) and 20 (5.1%) patients. On multivariate analyses, significant liver fibrosis was independently associated with increased risk of all-cause (hazard ratio [HR] 8.14, 95% CI 3.03-21.90, p < 0.001) and cardiovascular (HR 4.29, 95% CI 1.10-16.73, p = 0.036) mortality, whereas fatty liver was not (all p > 0.05). CONCLUSIONS: This study found that the burden of liver fibrosis but not that of steatosis, assessed via TE, was an independent predictor of all-cause and cardiovascular mortality during long-term follow-up in patients with ischaemic stroke.
BACKGROUND: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). - Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. RESULTS: Among 395 patients included in this study, there were 37 (9%) patients with significant fibrosis (> 8.0 kPa) and 164 (41.5%) patients with fatty liver (> 250 dB/m). During the follow-up period (median 2.7 years), all-cause and cardiovascular mortality occurred in 28 (7.1%) and 20 (5.1%) patients. On multivariate analyses, significant liver fibrosis was independently associated with increased risk of all-cause (hazard ratio [HR] 8.14, 95% CI 3.03-21.90, p < 0.001) and cardiovascular (HR 4.29, 95% CI 1.10-16.73, p = 0.036) mortality, whereas fatty liver was not (all p > 0.05). CONCLUSIONS: This study found that the burden of liver fibrosis but not that of steatosis, assessed via TE, was an independent predictor of all-cause and cardiovascular mortality during long-term follow-up in patients with ischaemic stroke.
Authors: Alejandro Campos-Murguía; Astrid Ruiz-Margáin; José A González-Regueiro; Ricardo U Macías-Rodríguez Journal: World J Gastroenterol Date: 2020-10-21 Impact factor: 5.742
Authors: Simon Fandler-Höfler; Rudolf E Stauber; Markus Kneihsl; Gerit Wünsch; Melanie Haidegger; Birgit Poltrum; Alexander Pichler; Hannes Deutschmann; Christian Enzinger; Peter Fickert; Thomas Gattringer Journal: Ther Adv Neurol Disord Date: 2021-08-31 Impact factor: 6.570