Dominique Musselman1, Neeta Shenvi2, Amita Manatunga2, Andrew H Miller3, Edward Lin4, Nana Gletsu-Miller5. 1. University of Miami Leonard H. Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, Miami, FL, United States. 2. Emory University School of Public Health, Department of Biostatistics, Atlanta, GA, United States. 3. Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, United States. 4. Emory University School of Medicine, Department of Surgery, Atlanta, GA, United States. 5. Department of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States. Electronic address: ngletsum@purdue.edu.
Abstract
BACKGROUND: Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery. METHODS: The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administered before, and at 6-months after RYGB surgery in severely obese women (body mass index > 35 kg/m2; N = 19). Symptom domains corresponding to depressed mood/suicide ideation, anxiety, cognitive, somatic, and neurovegetative symptoms were assessed. Biologic measures were of adiposity [leptin, abdominal visceral (VAT) and subcutaneous (SAT) adipose tissue], inflammation [IL-6, C-reactive protein (CRP)], and insulin sensitivity (Si). Spearman correlations and linear regression (adjusted for biologic measures) assessed relationships between changes in biologic measures and changes in neurobehavioral domains. RESULTS: By 6-months after RYGB, VAT, SAT, Si, CRP, and IL-6 had improved (p < .05). Anxiety, somatic, and neurovegetative symptoms domains improved (p < .05), but depressed mood/suicidal ideation and cognitive domains did not. Reductions in VAT were associated with decreases in neurovegetative symptoms (beta = 295 ± 85, p < .01). We also found significant positive longitudinal associations between IL-6 concentrations and minor changes in cognitive symptoms. CONCLUSION: Anxiety, somatic and neurovegetative symptoms, improved within 6 months after RYGB, but depressed mood/suicidal ideation and cognitive symptoms did not improve. Associations between visceral adiposity, IL-6 concentrations and neurovegetative and cognitive symptoms support links between obesity, inflammation and distinct neurobehavioral symptoms.
BACKGROUND:Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery. METHODS: The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administered before, and at 6-months after RYGB surgery in severely obesewomen (body mass index > 35 kg/m2; N = 19). Symptom domains corresponding to depressed mood/suicide ideation, anxiety, cognitive, somatic, and neurovegetative symptoms were assessed. Biologic measures were of adiposity [leptin, abdominal visceral (VAT) and subcutaneous (SAT) adipose tissue], inflammation [IL-6, C-reactive protein (CRP)], and insulin sensitivity (Si). Spearman correlations and linear regression (adjusted for biologic measures) assessed relationships between changes in biologic measures and changes in neurobehavioral domains. RESULTS: By 6-months after RYGB, VAT, SAT, Si, CRP, and IL-6 had improved (p < .05). Anxiety, somatic, and neurovegetative symptoms domains improved (p < .05), but depressed mood/suicidal ideation and cognitive domains did not. Reductions in VAT were associated with decreases in neurovegetative symptoms (beta = 295 ± 85, p < .01). We also found significant positive longitudinal associations between IL-6 concentrations and minor changes in cognitive symptoms. CONCLUSION:Anxiety, somatic and neurovegetative symptoms, improved within 6 months after RYGB, but depressed mood/suicidal ideation and cognitive symptoms did not improve. Associations between visceral adiposity, IL-6 concentrations and neurovegetative and cognitive symptoms support links between obesity, inflammation and distinct neurobehavioral symptoms.
Authors: Lucile Capuron; Jane F Gumnick; Dominique L Musselman; David H Lawson; Andrea Reemsnyder; Charles B Nemeroff; Andrew H Miller Journal: Neuropsychopharmacology Date: 2002-05 Impact factor: 7.853
Authors: Charles F Emery; Meghan D M Fondow; Carol M Schneider; Fievos L Christofi; Chantal Hunt; Andrea K Busby; Bradley J Needleman; W Scott Melvin; Hamdy M Elsayed-Awad Journal: Obes Surg Date: 2007-06 Impact factor: 4.129
Authors: Edward Lin; Nana Gletsu; Kim Fugate; David McClusky; Li H Gu; Juan-Li Zhu; Bruce J Ramshaw; Dimitris A Papanicolaou; Thomas R Ziegler; C Daniel Smith Journal: Arch Surg Date: 2004-07
Authors: James E Mitchell; Ross Crosby; Martina de Zwaan; Scott Engel; James Roerig; Kristine Steffen; Kathryn H Gordon; Trisha Karr; Jason Lavender; Steve Wonderlich Journal: Obesity (Silver Spring) Date: 2013-04 Impact factor: 5.002