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Literature DB >> 30763547

The linear No-Threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundations.

Abstract

The linear no-threshold (LNT) single-hit (SH) dose response model for cancer risk assessment is comprehensively assessed with respect to its historical foundations. This paper also examines how mistakes, ideological biases, and scientific misconduct by key scientists affected the acceptance, validity, and applications of the LNT model for cancer risk assessment. In addition, the analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication.

Entities: Disease

Keywords: Cancer risk assessment; Dose response; LNT; Linear dose response; Mutation, ionizing radiation; Single-hit

Mesh：

Year: 2019 PMID： 30763547 DOI： 10.1016/j.cbi.2018.11.020

Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192

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Cited

11 in total

1. Linear Non-Threshold (LNT) historical discovery milestones.

Authors: Edward Calabrese
Journal: Med Lav Date: 2022-08-25 Impact factor: 2.244

2. Exaggerated Risk Perception of Low-Dose Radiation: Motives and Mechanisms.

Authors: Sergei Jargin
Journal: Dose Response Date: 2022-05-18 Impact factor: 2.623

3. Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation.

Authors: Pamela J Sykes
Journal: Dose Response Date: 2020-04-26 Impact factor: 2.658

4. Toxic Responses Induced at High Doses May Affect Benchmark Doses.

Authors: Jürg A Zarn; Ursina A Zürcher; H Christoph Geiser
Journal: Dose Response Date: 2020-04-21 Impact factor: 2.658

Review 5. Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel mechanistic considerations.

Authors: Edward J Calabrese; Walter J Kozumbo; Rachna Kapoor; Gaurav Dhawan; Pedro C Lara; James Giordano
Journal: Radiother Oncol Date: 2021-04-28 Impact factor: 6.901

The linear No-Threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundations.

1. Linear Non-Threshold (LNT) historical discovery milestones.

2. Exaggerated Risk Perception of Low-Dose Radiation: Motives and Mechanisms.

3. Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation.

4. Toxic Responses Induced at High Doses May Affect Benchmark Doses.

Review 5. Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel mechanistic considerations.

6. Towards a toxic-free environment: perspectives for chemical risk assessment approaches.

7. Addressing Risk Perceptions of Low-Dose Radiation Exposure.

8. Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm.

9. The LNT Issue Is About Politics and Economics, Not Safety.

10. Effects of Chronic Low-Dose Internal Radiation on Immune-Stimulatory Responses in Mice.