| Literature DB >> 30763272 |
Nickolay K Isaev1,2, Elena V Stelmashook2, Elisaveta E Genrikhs2.
Abstract
Human aging affects the entire organism, but aging of the brain must undoubtedly be different from that of all other organs, as neurons are highly differentiated postmitotic cells, for the majority of which the lifespan in the postnatal period is equal to the lifespan of the entire organism. In this work, we examine the distinctive features of brain aging and neurogenesis during normal aging, pathological aging (Alzheimer's disease), and accelerated aging (Hutchinson-Gilford progeria syndrome and Werner syndrome).Entities:
Keywords: Alzheimer’s disease; Hutchinson-Gilford progeria syndrome; aging; brain; stem cells
Mesh:
Year: 2019 PMID: 30763272 DOI: 10.1515/revneuro-2018-0084
Source DB: PubMed Journal: Rev Neurosci ISSN: 0334-1763 Impact factor: 4.353