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Literature DB >> 30763106

Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.

Hai-Xue Pan¹, Zhang Chen, Tianfang Zeng², Wen-Bing Jin¹, Yujie Geng, Geng-Min Lin, Juan Zhao¹, Wei-Tao Li¹, Zijun Xiong³, Sheng-Xiong Huang³, Xin Zhai², Hung-Wen Liu, Gong-Li Tang¹.

Abstract

The biosynthetic gene clusters for herbicidins ( hbc) and aureonuclemycin ( anm) were identified in Streptomyces sp. KIB-027 and Streptomyces aureus, respectively. The roles of genes possibly involved in post-core-assembly steps in herbicidin biosynthesis in these clusters and a related her cluster were studied. Through systematic gene deletions, structural elucidation of the accumulated intermediates in the mutants, and in vitro verification of the encoded enzymes, the peripheral modification pathway for herbicidin biosynthesis is now fully established.

Entities: Chemical Disease Species

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Year: 2019 PMID： 30763106 PMCID： PMC6451440 DOI： 10.1021/acs.orglett.9b00066

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

16 in total

Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.

1. Stereoselective total syntheses of herbicidin C and aureonuclemycin through late-stage glycosylation.

2. 8'-epimer of herbicidin F and its congeners from Streptomyces sp. YIM 66142.

3. The revised structure of herbicidins.

4. Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity.

5. Total synthesis of herbicidin C and aureonuclemycin: impasses and new avenues.

6. A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis.

7. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.

8. Terminal steps in the biosynthesis of herbicidins, nucleoside antibiotics.

9. Herbicidins F and G, two new nucleoside antibiotics.

10. Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10.

1. Identification of the Early Steps in Herbicidin Biosynthesis Reveals an Atypical Mechanism of C-Glycosylation.

2. Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking.

3. Antibacterial Activity of Aureonuclemycin Produced by Streptomyces aureus Strain SPRI-371.