| Literature DB >> 30763072 |
Shaowei Wang1, Wenbo Wu1, Purnima Manghnani1, Shidang Xu1, Yuanbo Wang1, Chi Ching Goh2, Lai Guan Ng2, Bin Liu1.
Abstract
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (1O2) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1O2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.Entities:
Keywords: aggregation-induced emission; conjugated polymer; photodynamic therapy; photosensitizer; two-photon
Year: 2019 PMID： 30763072 DOI： 10.1021/acsnano.8b08398
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881