Juliane Schulz1,2, Carina Knappe1, Christian Graetz2, Louisa Mewes2, Kathrin Türk1, Anna K Black1, Wolfgang Lieb3, Arne S Schäfer4, Karim M Fawzy El-Sayed2,5, Christof E Dörfer2, Stefan Schreiber1,6, Matthias Laudes1,6, Dominik M Schulte1,6. 1. Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany. 2. Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany. 3. Institute of Epidemiology, Christian-Albrechts-University Kiel, Kiel, Germany. 4. Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Berlin, Germany. 5. Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt. 6. Cluster of Excellence, Inflammation at Interfaces, Christian-Albrechts-University Kiel, Kiel, Germany.
Abstract
AIM: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach. MATERIALS AND METHODS: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. A total of 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design. RESULTS: Systemic sFRP5 serum levels were significantly lower in patients with periodontitis and tooth loss (2.5 [0.0-10.4] ng/ml, median [IQR]) compared to patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR], p = 0.04] and matched controls (7.0 [2.5-18.3] ng/ml, median [IQR], p = 0.02). No significant differences in sFRP5 serum levels were found among patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR]) and controls (3.1 [0.0-10.6] ng/ml, median [IQR], p = 0.06). CONCLUSIONS: sFRP5 might serve as a novel biomarker for periodontitis severity. Modulating the inflammatory background of severe forms of periodontitis, in the time of precision medicine, needs to be revealed in further studies.
AIM: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in humanperiodontitis using an epidemiological approach. MATERIALS AND METHODS:sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. A total of 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design. RESULTS: Systemic sFRP5 serum levels were significantly lower in patients with periodontitis and tooth loss (2.5 [0.0-10.4] ng/ml, median [IQR]) compared to patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR], p = 0.04] and matched controls (7.0 [2.5-18.3] ng/ml, median [IQR], p = 0.02). No significant differences in sFRP5 serum levels were found among patients with periodontitis without tooth loss (6.0 [2.5-15.8] ng/ml, median [IQR]) and controls (3.1 [0.0-10.6] ng/ml, median [IQR], p = 0.06). CONCLUSIONS:sFRP5 might serve as a novel biomarker for periodontitis severity. Modulating the inflammatory background of severe forms of periodontitis, in the time of precision medicine, needs to be revealed in further studies.
Authors: Corinna Geisler; Kristina Schlicht; Carina Knappe; Nathalie Rohmann; Katharina Hartmann; Kathrin Türk; Ute Settgast; Dominik M Schulte; Tobias Demetrowitsch; Julia Jensen-Kroll; Alina Pisarevskaja; Fynn Brix; Bärbel Gruber; Gerald Rimbach; Frank Döring; Philip Rosenstiel; Andre Franke; Stefan Schreiber; Christian H C A Henning; Wolfgang Lieb; Ute Nöthlings; Karin Schwarz; Matthias Laudes Journal: Eur J Epidemiol Date: 2022-10-16 Impact factor: 12.434