Jessica J Chiang1, Heejung Park2, David M Almeida3, Julienne E Bower4, Steve W Cole5, Michael R Irwin4, Heather McCreath6, Teresa E Seeman6, Andrew J Fuligni4. 1. Institute for Policy Research. 2. Department of Psychology, Bryn Mawr College. 3. Department of Human Development and Family Studies, Pennsylvania State University. 4. Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles. 5. Department of Psychiatry and Biobehavioral Sciences and Cousins Center for Psychoneuroimmunology, University of California, Los Angeles. 6. Division of Geriatrics, Department of Medicine, University of California, Los Angeles.
Abstract
OBJECTIVE: Cardiovascular disease (CVD) is one of the most prevalent chronic conditions and leading causes of death. Although CVD clinically manifests in adulthood, underlying processes of CVD begin in the earlier decades of life. Inflammation has been shown to play a key role, but relatively little is understood about how inflammation changes over time among young individuals. Additionally, how psychosocial factors like stress may influence changes in inflammation earlier in the lifespan is not entirely clear. Thus, the current three-wave longitudinal study examined the developmental trajectory of CRP, a marker of systemic inflammation, over a 4-year period from mid-adolescence into young adulthood. Between- and within-person differences in stress in relation to changes in CRP were also examined. METHOD: A sample of 350 individuals was recruited during mid-adolescence and participated in 1 to 3 assessments, 2 years apart. At each assessment, participants provided dried blood spots for the assessment of CRP and reported on recent major life events, perceived stress, and daily interpersonal stress. RESULTS: Multilevel modeling indicated that CRP increased with age, and within-person increases in perceived stress, but not life events or daily stress, were associated with higher CRP. Between-person differences in average levels of stress from mid-adolescence into young adulthood were not associated with changes in CRP. CONCLUSION: These findings suggest that the link between stress and systemic inflammation between mid-adolescence and young adulthood may be most affected by contemporaneous experiences of perceived stress. There was little evidence to suggest that CRP trajectories varied by between-person differences in overall average levels of perceived stress, life events, and daily stress. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
OBJECTIVE:Cardiovascular disease (CVD) is one of the most prevalent chronic conditions and leading causes of death. Although CVD clinically manifests in adulthood, underlying processes of CVD begin in the earlier decades of life. Inflammation has been shown to play a key role, but relatively little is understood about how inflammation changes over time among young individuals. Additionally, how psychosocial factors like stress may influence changes in inflammation earlier in the lifespan is not entirely clear. Thus, the current three-wave longitudinal study examined the developmental trajectory of CRP, a marker of systemic inflammation, over a 4-year period from mid-adolescence into young adulthood. Between- and within-person differences in stress in relation to changes in CRP were also examined. METHOD: A sample of 350 individuals was recruited during mid-adolescence and participated in 1 to 3 assessments, 2 years apart. At each assessment, participants provided dried blood spots for the assessment of CRP and reported on recent major life events, perceived stress, and daily interpersonal stress. RESULTS: Multilevel modeling indicated that CRP increased with age, and within-person increases in perceived stress, but not life events or daily stress, were associated with higher CRP. Between-person differences in average levels of stress from mid-adolescence into young adulthood were not associated with changes in CRP. CONCLUSION: These findings suggest that the link between stress and systemic inflammation between mid-adolescence and young adulthood may be most affected by contemporaneous experiences of perceived stress. There was little evidence to suggest that CRP trajectories varied by between-person differences in overall average levels of perceived stress, life events, and daily stress. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Authors: Jessica J Chiang; Julienne E Bower; Michael R Irwin; Shelley E Taylor; Andrew J Fuligni Journal: Brain Behav Immun Date: 2017-06-28 Impact factor: 7.217
Authors: Mary-Frances O'Connor; Julie E Bower; Hyong Jin Cho; J David Creswell; Stoyan Dimitrov; Mary E Hamby; Michael A Hoyt; Jennifer L Martin; Theodore F Robles; Erica K Sloan; Kamala S Thomas; Michael R Irwin Journal: Brain Behav Immun Date: 2009-04-21 Impact factor: 7.217
Authors: Natalie Slopen; Laura D Kubzansky; Katie A McLaughlin; Karestan C Koenen Journal: Psychoneuroendocrinology Date: 2012-06-21 Impact factor: 4.905
Authors: Kate Ryan Kuhlman; Jessica J Chiang; Julienne E Bower; Michael R Irwin; Steve W Cole; Ronald E Dahl; David M Almeida; Andrew J Fuligni Journal: J Abnorm Child Psychol Date: 2020-01
Authors: Meredith O'Connor; Anne-Louise Ponsonby; Fiona Collier; Richard Liu; Peter D Sly; Peter Azzopardi; Kate Lycett; Sharon Goldfeld; Sarah J Arnup; David Burgner; Naomi Priest Journal: Brain Behav Immun Health Date: 2020-09-28