| Literature DB >> 30762374 |
Daojiang Yan1, Qibin Chen1, Jie Gao1, Jian Bai1, Bingyu Liu1, Yalong Zhang1, Le Zhang1, Chen Zhang1, Yi Zou2, Youcai Hu1.
Abstract
Fumiquinazolines are multicyclic peptidyl alkaloids where FAD-dependent oxidases are main tailing redox enzymes in their biosynthesis. Here, we characterized the use of an α-KG/Fe(II)-dependent dioxygenase (α-KGD) as a new strategy in Nature to increase structural complexity in fumiquinazolines biosynthesis by elucidating the concise three enzymes biosynthetic pathway of heptacyclical alanditrypinone (1). Further genome mining led to the discovery of additional gene cluster with α-KGD and trimodular NRPS as partner, which generates diverse fumiquinazolines.Entities:
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Year: 2019 PMID： 30762374 DOI： 10.1021/acs.orglett.9b00260
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005