Margrethe Langer Bro1,2, Christoffer Johansen3,4, Peter Vuust5, Lisbeth Enggaard6, Bodil Himmelstrup7, Torben Mourits-Andersen8, Peter Brown9, Francesco d'Amore10, Elisabeth Anne Wreford Andersen11, Niels Abildgaard12,13,14, Jeppe Gram15. 1. The Danish National Academy of Music, Odense, Denmark. mbro10@smksnet.dk. 2. Institute of Regional Health Science, University of Southern Denmark, J. B. Winsløws Vej 19, 5000, Odense, Denmark. mbro10@smksnet.dk. 3. Unit of Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark. 4. Oncology Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 5. Center for Music in the Brain, Institute of Clinical Medicine, Aarhus University and The Royal Academy of Music, Aarhus/Aalborg, Denmark. 6. Department of Haematology, Herlev Hospital, Herlev, Denmark. 7. Department of Haematology, Roskilde Hospital, Roskilde, Denmark. 8. Department of Haematology, Hospital of Southwest Denmark, Esbjerg, Denmark. 9. Department of Haematology, Rigshospitalet, Copenhagen, Denmark. 10. Department of Haematology, Aarhus University Hospital, Aarhus, Denmark. 11. Unit of Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark. 12. Department of Haematology, Odense University Hospital, Odense, Denmark. 13. Quality of Life Research OUH, Odense University Hospital, Odense, Denmark. 14. Academy of Geriatric Cancer Research, Odense University Hospital, Odense, Denmark. 15. Department of Endocrinology, Hospital of Southwest Jutland, Esbjerg, Jutland, Denmark.
Abstract
PURPOSE:Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients. METHODS: A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger's State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint. RESULTS: When adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7% (95% CI, - 14% to 0%, p = 0.05), while the effect of pre-recorded music was non-significant (5% (95% CI, - 12% to + 3%, p = 0.18). No intervention effects were seen in secondary outcomes. CONCLUSION: Our findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.
RCT Entities:
PURPOSE: Chemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphomapatients. METHODS: A total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger's State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint. RESULTS: When adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7% (95% CI, - 14% to 0%, p = 0.05), while the effect of pre-recorded music was non-significant (5% (95% CI, - 12% to + 3%, p = 0.18). No intervention effects were seen in secondary outcomes. CONCLUSION: Our findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.
Authors: C Panis; A C S A Herrera; V J Victorino; F C Campos; L F Freitas; T De Rossi; A N Colado Simão; A L Cecchini; R Cecchini Journal: Breast Cancer Res Treat Date: 2011-08-03 Impact factor: 4.872
Authors: Debra S Burns; Faouzi Azzouz; Renata Sledge; Cheryl Rutledge; Katie Hincher; Patrick O Monahan; Larry D Cripe Journal: Support Care Cancer Date: 2007-09-22 Impact factor: 3.603
Authors: Hsiu F Tsai; Ying R Chen; Min H Chung; Yuan M Liao; Mei J Chi; Chia C Chang; Kuei R Chou Journal: Cancer Nurs Date: 2014 Nov-Dec Impact factor: 2.592
Authors: Jianfei Xie; Ziyu Wan; Yinglong Duan; Miao Wang; Yating Luo; Panpan Xiao; Yue Kang; Yi Zhou; Xiaofei Luo; Qian Sun; Andy S K Cheng Journal: Support Care Cancer Date: 2022-03-28 Impact factor: 3.603
Authors: Talita Uchoa Lima; Ed Carlos Rey Moura; Caio Márcio Barros de Oliveira; Rachel Jorge Dino Cossetti Leal; João Nogueira Neto; Emanuel Cabral Pereira; Raniere Victor Braga Nascimento; Eduardo José Silva Gomes de Oliveira; Plínio da Cunha Leal Journal: Integr Cancer Ther Date: 2020 Jan-Dec Impact factor: 3.279