Literature DB >> 30761449

SOCS1 and its Potential Clinical Role in Tumor.

Jie Ying1, Xiaoyan Qiu1, Yu Lu1, Miaomiao Zhang2.   

Abstract

Suppressor of cytokine signaling1 (SOCS1), as a member of SOCS family, has been widely studied in recent years. It has been found that SOCS1 not only participates in cell signaling, but also in ubiquitination mediated protein degradation process. Both of these two functions play an important role in the growth and proliferation of cells. Therefore, researchers speculated that SOCS1 also played an important role in tumors. This review mainly focuses on the structure, transcriptional regulation and functions of SOCS1 protein, and finally describes the possible clinical role of SOCS1 protein in tumors.

Entities:  

Keywords:  Cell signaling; SOCS1; Tumors; Ubiquitination

Mesh：

Substances：

Year:  2019        PMID： 30761449     DOI： 10.1007/s12253-019-00612-5

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  82 in total

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Journal:  Swiss Med Wkly       Date:  2010-07-15       Impact factor: 2.193

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Journal:  J Immunol       Date:  2005-04-01       Impact factor: 5.422

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Journal:  Blood       Date:  2001-01-01       Impact factor: 22.113

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Journal:  J Recept Signal Transduct Res       Date:  2011-04       Impact factor: 2.092

6.  Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation.

Authors:  Li-Ming Wu; Feng Zhang; Lin Zhou; Zhe Yang; Hai-Yang Xie; Shu-Sen Zheng
Journal:  BMC Cancer       Date:  2010-08-02       Impact factor: 4.430

7.  Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma.

Authors:  Zhuo Li; Dieter Metze; Dorothea Nashan; Carsten Müller-Tidow; Hubert L Serve; Christopher Poremba; Thomas A Luger; Markus Böhm
Journal:  J Invest Dermatol       Date:  2004-10       Impact factor: 8.551

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Journal:  Br J Cancer       Date:  2007-10-30       Impact factor: 7.640

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Authors:  Qing-Yun Wu; Yuan-Yuan Zhu; Yang Liu; Fang Wei; Yu-Xue Tong; Jiang Cao; Ping Zhou; Ming-Shan Niu; Zhen-Yu Li; Ling-Yu Zeng; Feng Li; Kai-Lin Xu
Journal:  Cell Death Dis       Date:  2018-07-10       Impact factor: 8.469
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  7 in total

1.  Long noncoding RNA CASC2 suppresses esophageal squamous cell carcinoma progression by increasing SOCS1 expression.

Authors:  Ke Sun; Guangping Zhang
Journal:  Cell Biosci       Date:  2019-11-09       Impact factor: 7.133

2.  Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1.

Authors:  Peng Zhang; Jingda Yu; Yifang Gui; Cui Sun; Weiping Han
Journal:  Yonsei Med J       Date:  2019-11       Impact factor: 2.759

3.  Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/SOCS1 Axis.

Authors:  Weipeng Liu; Xin Zhou; Yuanqiang Li; Hong Jiang; Aijun Chen
Journal:  J Breast Cancer       Date:  2021-06       Impact factor: 3.588

4.  Solid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway.

Authors:  Chuanfeng Lv; Hui Li; Hongxia Cui; Qianyu Bi; Meng Wang
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

5.  Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma.

Authors:  Zhang-Wei Hu; Yi-Hui Wen; Ren-Qiang Ma; Lin Chen; Xue-Lan Zeng; Wei-Ping Wen; Wei Sun
Journal:  Front Cell Dev Biol       Date:  2021-08-30

6.  SOCS1 blocks G1-S transition in hepatocellular carcinoma by reducing the stability of the CyclinD1/CDK4 complex in the nucleus.

Authors:  Jun Ding; Kangdi Xu; Suwan Sun; Chao Qian; Shengyong Yin; Haiyang Xie; Lin Zhou; Shusen Zheng; Wei Zhang
Journal:  Aging (Albany NY)       Date:  2020-02-25       Impact factor: 5.682

7.  Outstanding prognostic value of novel ferroptosis-related genes in chemoresistance osteosarcoma patients.

Authors:  Jiazheng Zhao; Yi Zhao; Xiaowei Ma; Helin Feng; Litao Jia
Journal:  Sci Rep       Date:  2022-03-23       Impact factor: 4.379
  7 in total

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