Nwora Lance Okeke1, Damian M Craig2, Michael J Muehlbauer2, Olga Ilkayeva2, Meredith E Clement1, Susanna Naggie1,3, Svati H Shah2,4,5. 1. Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 315 Trent Drive, Rm. 178, Durham, NC 27710, USA. 2. Duke Molecular Physiology Institute, Durham, NC, USA. 3. Duke Clinical Research Institute, Durham, NC, USA. 4. Duke Global Health Institute, Durham, NC, USA. 5. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Abstract
Introduction: Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking. Methods: Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis. Results: Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls. Conclusion: SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.
Introduction: Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking. Methods: Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis. Results: Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls. Conclusion: SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.
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