Literature DB >> 3076052

Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes.

H Hauner1, G Glatting, D Kaminska, E F Pfeiffer.   

Abstract

The effects of gastric inhibitory polypeptide (GIP) on glucose and lipid metabolism of isolated rat adipocytes were investigated. In a dose-dependent manner, GIP stimulated 2-deoxy-glucose uptake increasing the glucose transport rate by up to 140% at a concentration of 10(-7) mol/l. GIP also stimulated the conversion of 14C-glucose into extractable lipids by up to 81% at 10(-7) mol/l. Insulin-stimulated 2-deoxy-glucose uptake and lipogenesis were additively enhanced by the presence of GIP. Insulin binding was slightly but not significantly increased by addition of GIP, mainly due to an increase in receptor affinity. GIP had a weak lipolytic activity, but lipolysis elicited by glucagon or isoproterenol was potently reduced. In conclusion, independent of its insulinotropic action, GIP showed a insulin-like activity on glucose metabolism and lipolysis in rat adipose tissue. The possible role of GIP for the development of obesity is discussed.

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Year:  1988        PMID： 3076052     DOI： 10.1159/000177467

Source DB:  PubMed          Journal:  Ann Nutr Metab        ISSN： 0250-6807            Impact factor:   3.374


  19 in total

1.  Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.

Authors:  C E Moss; W J Marsh; H E Parker; E Ogunnowo-Bada; C H Riches; A M Habib; M L Evans; F M Gribble; F Reimann
Journal:  Diabetologia       Date:  2012-08-08       Impact factor: 10.122

2.  GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial.

Authors:  Özlem Gögebakan; Martin A Osterhoff; Rita Schüler; Olga Pivovarova; Michael Kruse; Anne-Cathrin Seltmann; Alexander S Mosig; Natalia Rudovich; Michael Nauck; Andreas F H Pfeiffer
Journal:  Diabetologia       Date:  2015-05-21       Impact factor: 10.122

Review 3.  GIP and bariatric surgery.

Authors:  Raghavendra S Rao; Subhash Kini
Journal:  Obes Surg       Date:  2011-02       Impact factor: 4.129

4.  Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.

Authors:  Randi Ugleholdt; Jens Pedersen; Maria Rosaria Bassi; Ernst-Martin Füchtbauer; Signe Marie Jørgensen; Hanne-Louise Kissow; Nikolaj Nytofte; Steen Seier Poulsen; Mette Marie Rosenkilde; Yutaka Seino; Peter Thams; Peter Johannes Holst; Jens Juul Holst
Journal:  J Biol Chem       Date:  2011-10-25       Impact factor: 5.157

5.  Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.

Authors:  Matthew C Althage; Eric L Ford; Songyan Wang; Patrick Tso; Kenneth S Polonsky; Burton M Wice
Journal:  J Biol Chem       Date:  2008-04-17       Impact factor: 5.157

6.  Ablation of leptin signaling to somatotropes: changes in metabolic factors that cause obesity.

Authors:  Noor Akhter; Angela K Odle; Melody L Allensworth-James; Anessa C Haney; Mohsin M Syed; Michael A Cozart; Streamson Chua; Rhonda Kineman; Gwen V Childs
Journal:  Endocrinology       Date:  2012-08-03       Impact factor: 4.736

7.  Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation.

Authors:  Diane H Song; Lisa Getty-Kaushik; Eva Tseng; Jonathan Simon; Barbara E Corkey; M Michael Wolfe
Journal:  Gastroenterology       Date:  2007-09-14       Impact factor: 22.682

8.  Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.

Authors:  Kazuyo Suzuki; Norio Harada; Shunsuke Yamane; Yasuhiko Nakamura; Kazuki Sasaki; Daniela Nasteska; Erina Joo; Kimitaka Shibue; Takanari Harada; Akihiro Hamasaki; Kentaro Toyoda; Kazuaki Nagashima; Nobuya Inagaki
Journal:  J Biol Chem       Date:  2012-11-28       Impact factor: 5.157

9.  Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis.

Authors:  Laure-Emmanuelle Zaragosi; Brigitte Wdziekonski; Kevin Le Brigand; Phi Villageois; Bernard Mari; Rainer Waldmann; Christian Dani; Pascal Barbry
Journal:  Genome Biol       Date:  2011-07-18       Impact factor: 13.583

10.  Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.

Authors:  Holly E Bates; Jonathan E Campbell; John R Ussher; Laurie L Baggio; Adriano Maida; Yutaka Seino; Daniel J Drucker
Journal:  Diabetes       Date:  2011-10-31       Impact factor: 9.461
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