Flávia Campos Lucena1, Eura Martins Lage2, Patrícia Gonçalves Teixeira2, Alexandre Simões Barbosa2, Rejane Diniz3, Bashir Lwaleed4, André Talvani5, Patrícia Nessralla Alpoim1, Luiza Oliveira Perucci6, Luci Maria SantAna Dusse1. 1. a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Federal University of Minas Gerais , Belo Horizonte , Brazil. 2. b Department of Gynecology and Obstetrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brazil. 3. c Department of Epidemiology , Veterinary School, Federal University of Minas Gerais , Belo Horizonte , Brazil. 4. d Department of Urology , University of Soutampton , Southampton , UK. 5. e Department of Biological Sciences, Institute of Exact and Biological Sciences , Federal University of Ouro Preto , Ouro Preto , Brazil. 6. f Nucleus of Research in Biological Sciences , Federal University of Ouro Preto , Ouro Preto , Brazil.
Abstract
OBJECTIVE: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. METHODS: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation. RESULTS: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn't differ between groups. CONCLUSION: D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation.
OBJECTIVE: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors. METHODS: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation. RESULTS: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. D-Di increased throughout gestation in both groups, peaking earlier in pregnant women who developed PE versus who did not develop it. PA1-1 increased across gestation, but it didn't differ between groups. CONCLUSION: D-Di was able to discriminate these groups of women at 12-19 and 30-34 weeks of gestation.
Entities:
Keywords:
D-dimer; PAI-1; Preeclampsia; hypercoagulability; longitudinal study