Sebastiano Leone1, Marco Cascella2, Ilaria Pezone3, Marco Fiore4. 1. a Division of Infectious Diseases , " San Giuseppe Moscati" Hospital , Avellino , Italy. 2. b Division of Anesthesia and Pain Medicine , Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale , Naples , Italy. 3. c Department of Pediatrics , " San Giuseppe Moscati" Hospital , Naples , Italy. 4. d Department of Women Child and General and Specialized Surgery , University of Campania "Luigi Vanvitelli" , Naples , Italy.
Abstract
Objective: Nowadays, the infections of patients admitted to intensive care units (ICUs) are a major public health problem; this is due to several factors, in primis an increase in antibiotic resistance and the inappropriate use of antibiotics. Methods: We briefly focus on on both new antibiotics approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the last decade (2010-2019), and on agents in an advanced phase of development that have been developed, or are already approved, for the treatment of serious infections due to multidrug-resistant bacteria, both Gram-positive and Gram-negative bacteria. Results: An adequate knowledge of the new antibiotics will reduce their inappropriate use with the consequent reduction in the onset of new resistance and decreasing health care costs. Conclusion: Antimicrobial stewardship programs to optimize antimicrobial prescribing and to preserve the effectiveness of the new antimicrobial agents are urgently needed'.
Objective: Nowadays, the infections of patients admitted to intensive care units (ICUs) are a major public health problem; this is due to several factors, in primis an increase in antibiotic resistance and the inappropriate use of antibiotics. Methods: We briefly focus on on both new antibiotics approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the last decade (2010-2019), and on agents in an advanced phase of development that have been developed, or are already approved, for the treatment of serious infections due to multidrug-resistant bacteria, both Gram-positive and Gram-negative bacteria. Results: An adequate knowledge of the new antibiotics will reduce their inappropriate use with the consequent reduction in the onset of new resistance and decreasing health care costs. Conclusion: Antimicrobial stewardship programs to optimize antimicrobial prescribing and to preserve the effectiveness of the new antimicrobial agents are urgently needed'.
Entities:
Keywords:
Intensive care unit infections; antibacterial agents; critically ill patients; multidrug-resistant organisms
Authors: Marco Fiore; Sveva Di Franco; Aniello Alfieri; Maria Beatrice Passavanti; Maria Caterina Pace; Stephen Petrou; Francesca Martora; Sebastiano Leone Journal: World J Hepatol Date: 2020-12-27