Michal Shteinberg1,2, Anand Shah3,2, J Stuart Elborn3. 1. Pulmonology Institute and CF Center, Carmel Medical Center and the Technion-Israel Institute of Technology, the B. Rappaport Faculty of Medicine, Haifa, Israel. 2. Both authors contributed equally to the manuscript. 3. Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.