| Literature DB >> 30759369 |
Petra Henrich-Noack1, Dragana Nikitovic2, Monica Neagu3, Anca Oana Docea4, Ayse Basak Engin5, Svetlana Gelperina6, Michael Shtilman6, Panayiotis Mitsias7, George Tzanakakis2, Illana Gozes8, Aristidis Tsatsakis9.
Abstract
Restrained drug delivery due to the blood-brain barrier (BBB) considerably limits options for the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been proposed as a solution. The development strategies need to address the important hurdle of NP passage across the BBB as well as the altered cellular up-take due to the pathophysiological changes of the damaged or diseased tissue as well as immunological and toxicological aspects of nanomedicine penetration. This review therefore scopes to: 1) outline the state-of-the art knowledge on BBB passage, 2) address the significant influence of pathological conditions on nanoparticulate drug delivery, and, 3) highlight the largely neglected role of the extracellular matrix (ECM). Interactions of the nanosystem with biological barriers, cells and ECM in the milieu of brain pathologies are critically discussed in order to present a holistic overview of the advances and pits of nanomedicine applications in brain disease.Entities:
Keywords: Blood-brain barrier; Brain pathology; Extracellular matrix; Nanomedicine; Neuropharmacology
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Year: 2019 PMID： 30759369 DOI： 10.1016/j.nano.2019.01.016
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307