Marcin Januszewski1, Tadeusz Issat1,2, Alicja A Jakimiuk3, Malgorzata Santor-Zaczynska1, Artur J Jakimiuk4,5. 1. Department of Obstetrics and Gynecology, Central Clinical Hospital of Interior, Warsaw, Poland. 2. Center of Reproductive Health, Institute of Mother and Child, Warsaw, Poland. 3. First Faculty of Medicine, Medical University of Warsaw, Poland. 4. Department of Obstetrics and Gynecology, Central Clinical Hospital of Interior, Warsaw, Poland. jakimiuk@yahoo.com. 5. Center of Reproductive Health, Institute of Mother and Child, Warsaw, Poland. jakimiuk@yahoo.com.
Abstract
OBJECTIVES: To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number - EUPAS25705 Material and methods: Seventy women diagnosed with PCOS according to the Rotterdam criteria were enrolled in this study. Patients received a combined therapy of one tablet that contained 550 mg of inositol (myo-inositol (MI) and D-chiro-inositol (DCI) in a ratio of 10:1) twice a day for 6 months. At each of 3 visits, the body weight, height and BMI were all recorded; and serum levels of free testosterone (fT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and glucose with insulin during standard OGTT (75 g) were measured. Also at each visit, transvaginal ultrasonography and skin condition assessments were performed. RESULTS: Significant body weight reduction and decreases in fT, FSH, LH and insulin levels, as well as significant increase of serum SHBG concentrations were observed. Serum glucose levels during OGTT decreased after 6 months of treatment. Also, skin conditions improved after only three months of treatment. CONCLUSIONS: Combination of MI and DCI in a ratio 10:1 seems to be efficient in improving both metabolic and hormonal parameters in patients with PCOS.
OBJECTIVES: To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number - EUPAS25705 Material and methods: Seventy women diagnosed with PCOS according to the Rotterdam criteria were enrolled in this study. Patients received a combined therapy of one tablet that contained 550 mg of inositol (myo-inositol (MI) and D-chiro-inositol (DCI) in a ratio of 10:1) twice a day for 6 months. At each of 3 visits, the body weight, height and BMI were all recorded; and serum levels of free testosterone (fT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and glucose with insulin during standard OGTT (75 g) were measured. Also at each visit, transvaginal ultrasonography and skin condition assessments were performed. RESULTS: Significant body weight reduction and decreases in fT, FSH, LH and insulin levels, as well as significant increase of serum SHBG concentrations were observed. Serum glucose levels during OGTT decreased after 6 months of treatment. Also, skin conditions improved after only three months of treatment. CONCLUSIONS: Combination of MI and DCI in a ratio 10:1 seems to be efficient in improving both metabolic and hormonal parameters in patients with PCOS.
Authors: V Soldat-Stanković; S Popović-Pejičić; S Stanković; A Prtina; G Malešević; J Bjekić-Macut; S Livadas; S Ognjanović; G Mastorakos; D Micić; D Macut Journal: J Endocrinol Invest Date: 2021-10-19 Impact factor: 4.256
Authors: Anna Wojciechowska; Adam Osowski; Marcin Jóźwik; Ryszard Górecki; Andrzej Rynkiewicz; Joanna Wojtkiewicz Journal: Int J Mol Sci Date: 2019-11-18 Impact factor: 5.923