Hanze Chen1, Beidi Zhang2, Weishuang Xue1, Jinwei Li1, Yuru Li1, Kailei Fu1, Xinxin Chen1, Miao Sun1, Han Shi3, Li Tian4, Weiyu Teng5. 1. Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China. 2. Department of Endodontics, School of Stomatology, China Medical University, Shenyang, China. 3. Clinical Department One, China Medical University, Shenyang, China. 4. Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China. tianlicmu2@126.com. 5. Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China. tengweiyucmu@sina.com.
Abstract
OBJECTIVE: A growing number of studies have been conducted on the relationship between anger and hostility and the risk of stroke, and their conclusions are not consistent. Accordingly, we performed a meta-analysis to evaluate the relationship between anger and hostility and the risk of stroke. METHODS: We searched the PubMed and Embase databases for cohort studies, focusing on the relationship between anger and hostility and risk of stroke. Then studies were selected according to the inclusion and exclusion criteria. Study results were pooled using a random effects model. RESULTS: Ten studies from seven articles involving 52,277 participants were included in this meta-analysis. No significant association was found between anger and hostility level and risk of stroke (hazard ratio 1.08; 95% confidence interval 0.79-1.47). However, a positive association was seen when people with high socioeconomic status were excluded (hazard ratio 1.30; 95% confidence interval 1.06-1.59). CONCLUSION: A higher level of anger and hostility is not associated with elevated risk of stroke. However, the association is positive among people with lower socioeconomic status.
OBJECTIVE: A growing number of studies have been conducted on the relationship between anger and hostility and the risk of stroke, and their conclusions are not consistent. Accordingly, we performed a meta-analysis to evaluate the relationship between anger and hostility and the risk of stroke. METHODS: We searched the PubMed and Embase databases for cohort studies, focusing on the relationship between anger and hostility and risk of stroke. Then studies were selected according to the inclusion and exclusion criteria. Study results were pooled using a random effects model. RESULTS: Ten studies from seven articles involving 52,277 participants were included in this meta-analysis. No significant association was found between anger and hostility level and risk of stroke (hazard ratio 1.08; 95% confidence interval 0.79-1.47). However, a positive association was seen when people with high socioeconomic status were excluded (hazard ratio 1.30; 95% confidence interval 1.06-1.59). CONCLUSION: A higher level of anger and hostility is not associated with elevated risk of stroke. However, the association is positive among people with lower socioeconomic status.