Literature DB >> 30755307

Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.

Jesse J McClure1, Viswanathan Palanisamy2.   

Abstract

The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures. We suggest that these unique isoforms play a role in the pathogenesis of HNSCC.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  FXR1; isoforms; muscle; squamous cell carcinoma

Mesh：

Substances：

Year:  2018        PMID： 30755307      PMCID： PMC6404231          DOI： 10.1016/j.trecan.2018.12.001

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  11 in total

1.  Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.

Authors:  Thomas L Gallagher; Joshua A Arribere; Paul A Geurts; Cameron R T Exner; Kent L McDonald; Kariena K Dill; Henry L Marr; Shaunak S Adkar; Aaron T Garnett; Sharon L Amacher; John G Conboy
Journal:  Dev Biol       Date:  2011-09-07       Impact factor: 3.582

2.  Alternative splicing in the murine and human FXR1 genes.

Authors:  L L Kirkpatrick; K A McIlwain; D L Nelson
Journal:  Genomics       Date:  1999-07-15       Impact factor: 5.736

3.  Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung.

Authors:  Nicole Comtesse; Andreas Keller; Isabel Diesinger; Christine Bauer; Klaus Kayser; Hanno Huwer; Hans-Peter Lenhof; Eckart Meese
Journal:  Int J Cancer       Date:  2007-06-15       Impact factor: 7.396

4.  Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients.

Authors:  L Davidovic; S Sacconi; E G Bechara; S Delplace; M Allegra; C Desnuelle; B Bardoni
Journal:  J Med Genet       Date:  2008-07-15       Impact factor: 6.318

5.  The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers.

Authors:  Jun Qian; Mohamed Hassanein; Megan D Hoeksema; Bradford K Harris; Yong Zou; Heidi Chen; Pengcheng Lu; Rosana Eisenberg; Jing Wang; Allan Espinosa; Xiangming Ji; Fredrick T Harris; S M Jamshedur Rahman; Pierre P Massion
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-02       Impact factor: 11.205

6.  Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure.

Authors:  Elias Bechara; Laetitia Davidovic; Mireille Melko; Mounia Bensaid; Sandra Tremblay; Josiane Grosgeorge; Edouard W Khandjian; Enzo Lalli; Barbara Bardoni
Journal:  Nucleic Acids Res       Date:  2006-12-14       Impact factor: 16.971

7.  Muscle specific fragile X related protein 1 isoforms are sequestered in the nucleus of undifferentiated myoblast.

Authors:  M Dubé; M E Huot; E W Khandjian
Journal:  BMC Genet       Date:  2000-12-07       Impact factor: 2.797

8.  A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability.

Authors:  Laetitia Davidovic; Nelly Durand; Olfa Khalfallah; Ricardo Tabet; Pascal Barbry; Bernard Mari; Sabrina Sacconi; Hervé Moine; Barbara Bardoni
Journal:  PLoS Genet       Date:  2013-03-21       Impact factor: 5.917

9.  MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells.

Authors:  B Cardinali; M Cappella; C Provenzano; J M Garcia-Manteiga; D Lazarevic; D Cittaro; F Martelli; G Falcone
Journal:  Cell Death Dis       Date:  2016-02-04       Impact factor: 8.469

10.  RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC.

Authors:  Mrinmoyee Majumder; Reniqua House; Nallasivam Palanisamy; Shuo Qie; Terrence A Day; David Neskey; J Alan Diehl; Viswanathan Palanisamy
Journal:  PLoS Genet       Date:  2016-09-08       Impact factor: 5.917
View more
  4 in total

Review 1.  The E3 Ubiquitin Ligase Fbxo4 Functions as a Tumor Suppressor: Its Biological Importance and Therapeutic Perspectives.

Authors:  Shuo Qie
Journal:  Cancers (Basel)       Date:  2022-04-25       Impact factor: 6.575

Review 2.  Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer.

Authors:  Mrinmoyee Majumder; Roger H Johnson; Viswanathan Palanisamy
Journal:  Crit Rev Biochem Mol Biol       Date:  2020-09-02       Impact factor: 8.250

3.  Protein and Signaling Pathway Responses to rhIL-6 Intervention Before Lobaplatin Treatment in Osteosarcoma Cells.

Authors:  Huan Wang; Bin Li; Kang Yan; Yonghong Wu; Yanhua Wen; Yunyan Liu; Pei Fan; Qiong Ma
Journal:  Front Oncol       Date:  2021-03-09       Impact factor: 6.244

4.  Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.

Authors:  Laura Nordio; Chiara Bazzocchi; Francesca Genova; Valentina Serra; Maria Longeri; Giovanni Franzo; Marco Rondena; Damiano Stefanello; Chiara Giudice
Journal:  Front Vet Sci       Date:  2021-12-13
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.