Deema Al-Shammery1, Dimitrios Michelogiannakis2, Zain Uddin Ahmed3, Hameeda Bashir Ahmed4, P Emile Rossouw5, Georgios E Romanos6, Fawad Javed7. 1. Department of Orthodontics, College of Dentistry, Riyadh Elm University, Riyadh, Saudi Arabia. Electronic address: deema@riyadh.edu.sa. 2. Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, NY, USA; Department of Community Dentistry and Oral Disease Prevention, Eastman Institute for Oral Health, University of Rochester, NY, USA. 3. Department of Surgery, Tertiary Cancer Center, NY, USA. 4. Private Dental Practice, Doha, Qatar. 5. Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, NY, USA. 6. Department of Periodontology, Stony Brook University, Stony Brook, NY, USA. 7. Department of Periodontology, Stony Brook University, Stony Brook, NY, USA; Laboratory for Periodontal-, Implant-, Phototherapy (LA-PIP), School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
Abstract
BACKGROUND: The aim of the present study was to comprehensively review indexed literature regarding the potential role of antimicrobial photodynamic therapy (aPDT) in Orthodontics. METHODS: Indexed databases were searched up to and including January 2019 using the following key words: (a) antimicrobial photodynamic therapy; (b) antimicrobial photodynamic chemotherapy; (c) orthodontic; and (d) orthodontics. Original (clinical and experimental) studies, case-reports, and case-series were included. Letters to the Editor, commentaries and review articles were excluded. RESULTS: Out of the 29 studies identified in the initial search, 4 studies were processed for data extraction. Three studies were randomized clinical trials performed in humans and 1 study was experimental. Results from 2 studies showed that aPDT is effective in the treatment of gingival inflammation in patients undergoing orthodontic therapy (OT). One study showed that oral decontamination can be successfully performed using aPDT among patients undergoing OT. Results of the experimental study showed that aPDT helps in surface decontamination of orthodontic instruments. CONCLUSION: There is insufficient evidence in indexed literature to justify the potential role of aPDT in OT. Hence, further studies are required in this regard.
BACKGROUND: The aim of the present study was to comprehensively review indexed literature regarding the potential role of antimicrobial photodynamic therapy (aPDT) in Orthodontics. METHODS: Indexed databases were searched up to and including January 2019 using the following key words: (a) antimicrobial photodynamic therapy; (b) antimicrobial photodynamic chemotherapy; (c) orthodontic; and (d) orthodontics. Original (clinical and experimental) studies, case-reports, and case-series were included. Letters to the Editor, commentaries and review articles were excluded. RESULTS: Out of the 29 studies identified in the initial search, 4 studies were processed for data extraction. Three studies were randomized clinical trials performed in humans and 1 study was experimental. Results from 2 studies showed that aPDT is effective in the treatment of gingival inflammation in patients undergoing orthodontic therapy (OT). One study showed that oral decontamination can be successfully performed using aPDT among patients undergoing OT. Results of the experimental study showed that aPDT helps in surface decontamination of orthodontic instruments. CONCLUSION: There is insufficient evidence in indexed literature to justify the potential role of aPDT in OT. Hence, further studies are required in this regard.
Authors: Marcin Olek; Agnieszka Machorowska-Pieniążek; Wojciech Stós; Janusz Kalukin; Dorota Bartusik-Aebisher; David Aebisher; Grzegorz Cieślar; Aleksandra Kawczyk-Krupka Journal: Pharmaceutics Date: 2021-05-14 Impact factor: 6.321