Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Microfluidics as an Emerging Precision Tool in Developmental Biology.

Literature DB >> 30753835

Microfluidics as an Emerging Precision Tool in Developmental Biology.

Katharina F Sonnen¹, Christoph A Merten².

Abstract

Microfluidics has become a precision tool in modern biology. It enables omics data to be obtained from individual cells, as compared to averaged signals from cell populations, and it allows manipulation of biological specimens in entirely new ways. Cells and organisms can be perturbed at extraordinary spatiotemporal resolution, revealing mechanistic insights that would otherwise remain hidden. In this perspective article, we discuss the current and future impact of microfluidic technology in the field of developmental biology. In addition, we provide detailed information on how to start using this technology even without prior experience.

Keywords: microfluidics; perturbation; single-cell analysis; spatiotemporal resolution

Mesh：

Year: 2019 PMID： 30753835 DOI： 10.1016/j.devcel.2019.01.015

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

Keyword Cloud
Cited

15 in total

1. Microfluidics on the fly: Inexpensive rapid fabrication of thermally laminated microfluidic devices for live imaging and multimodal perturbations of multicellular systems.

Authors: Megan Levis; Nilay Kumar; Emily Apakian; Cesar Moreno; Ulises Hernandez; Ana Olivares; Fernando Ontiveros; Jeremiah J Zartman
Journal: Biomicrofluidics Date: 2019-04-26 Impact factor: 2.800

Review 2. Organelle size scaling over embryonic development.

Authors: Chase C Wesley; Sampada Mishra; Daniel L Levy
Journal: Wiley Interdiscip Rev Dev Biol Date: 2020-01-31 Impact factor: 5.814

3. Microfluidic systems for modeling human development.

Authors: Makenzie G Bonner; Hemanth Gudapati; Xingrui Mou; Samira Musah
Journal: Development Date: 2022-02-14 Impact factor: 6.868

Review 4. Regulation of organelle size and organization during development.

Authors: Pan Chen; Daniel L Levy
Journal: Semin Cell Dev Biol Date: 2022-02-08 Impact factor: 7.499

5. Toward embryo cryopreservation-on-a-chip: A standalone microfluidic platform for gradual loading of cryoprotectants to minimize cryoinjuries.

Authors: Pouria Tirgar; Fatemeh Sarmadi; Mojgan Najafi; Parinaz Kazemi; Sina AzizMohseni; Samaneh Fayazi; Ghazaleh Zandi; Nikta Ziaie; Aida Shoushtari Zadeh Naseri; Allen Ehrlicher; Mojtaba Dashtizad
Journal: Biomicrofluidics Date: 2021-05-18 Impact factor: 2.800

Microfluidics as an Emerging Precision Tool in Developmental Biology.

1. Microfluidics on the fly: Inexpensive rapid fabrication of thermally laminated microfluidic devices for live imaging and multimodal perturbations of multicellular systems.

Review 2. Organelle size scaling over embryonic development.

3. Microfluidic systems for modeling human development.

Review 4. Regulation of organelle size and organization during development.

5. Toward embryo cryopreservation-on-a-chip: A standalone microfluidic platform for gradual loading of cryoprotectants to minimize cryoinjuries.

6. Developmental Physiology: Grand Challenges.

7. Building bridges between fields: bringing together development and homeostasis.

Review 8. The advantages of microfluidics to study actin biochemistry and biomechanics.

9. Collective behaviors of Drosophila-derived retinal progenitors in controlled microenvironments.

10. Invertebrate Retinal Progenitors as Regenerative Models in a Microfluidic System.