Taoping Sun1,2, Yanwei Zhang3, Hao Huang1,2, Xiaoqian Wang1,2, Li Zhou3, Shuzhen Li1,2, Suli Huang3, Changhui Xie3, Ying Wen3, Yalun Zhu1,2, Xiaoli Hu1,2, Liangkai Chen1,2, Peiyun Li1,2, Sijing Chen1,2, Wei Yang1,2, Wei Bao4, Frank B Hu5,6, Jinquan Cheng3, Liegang Liu1,2. 1. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety. 2. Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 3. Shenzhen Center for Disease Control and Prevention, Shenzhen, China. 4. Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA. 5. Department of Nutrition. 6. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.
Abstract
Background: Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association. Objectives: The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke. Methods: A hospital-based case-control study was conducted between March 2011 and May 2016. Cases (n = 990) with first ischemic stroke were matched to controls (n = 990) by sex and age. Concentrations of plasma DHPPA were determined by high-performance liquid chromatography-tandem mass spectrometry. We calculated ORs for the association of plasma DHPPA concentrations with ischemic stroke risk through the use of logistic regression. Results: Plasma DHPPA was inversely associated with ischemic stroke risk. After adjustment for potential confounding factors, the ORs for ischemic stroke across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.76 (95% CI: 0.58, 0.99), 0.71 (95% CI: 0.54, 0.92), and 0.59 (95% CI: 0.45, 0.77), respectively (P-trend = 0.001). The inverse association was also observed in all subgroups of participants according to sex, age, body mass index, smoking status, alcohol consumption, history of hypertension, and history of diabetes. Conclusions: Our study showed that higher plasma DHPPA concentrations were associated with lower risk of ischemic stroke. This finding provides further evidence to support the health benefits of whole-grain consumption.
Background: Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association. Objectives: The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke. Methods: A hospital-based case-control study was conducted between March 2011 and May 2016. Cases (n = 990) with first ischemic stroke were matched to controls (n = 990) by sex and age. Concentrations of plasma DHPPA were determined by high-performance liquid chromatography-tandem mass spectrometry. We calculated ORs for the association of plasma DHPPA concentrations with ischemic stroke risk through the use of logistic regression. Results: Plasma DHPPA was inversely associated with ischemic stroke risk. After adjustment for potential confounding factors, the ORs for ischemic stroke across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.76 (95% CI: 0.58, 0.99), 0.71 (95% CI: 0.54, 0.92), and 0.59 (95% CI: 0.45, 0.77), respectively (P-trend = 0.001). The inverse association was also observed in all subgroups of participants according to sex, age, body mass index, smoking status, alcohol consumption, history of hypertension, and history of diabetes. Conclusions: Our study showed that higher plasma DHPPA concentrations were associated with lower risk of ischemic stroke. This finding provides further evidence to support the health benefits of whole-grain consumption.
Authors: Padma Maruvada; Johanna W Lampe; David S Wishart; Dinesh Barupal; Deirdra N Chester; Dylan Dodd; Yannick Djoumbou-Feunang; Pieter C Dorrestein; Lars O Dragsted; John Draper; Linda C Duffy; Johanna T Dwyer; Nancy J Emenaker; Oliver Fiehn; Robert E Gerszten; Frank B Hu; Robert W Karp; David M Klurfeld; Maren R Laughlin; A Roger Little; Christopher J Lynch; Steven C Moore; Holly L Nicastro; Diane M O'Brien; José M Ordovás; Stavroula K Osganian; Mary Playdon; Ross Prentice; Daniel Raftery; Nichole Reisdorph; Helen M Roche; Sharon A Ross; Shengmin Sang; Augustin Scalbert; Pothur R Srinivas; Steven H Zeisel Journal: Adv Nutr Date: 2020-03-01 Impact factor: 11.567