A E T Brito1,2, F A Mourato3, R P M de Oliveira3, A L G Leal3, P J A Filho3, J L L de Filho4. 1. Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil. aetbrito@gmail.com. 2. Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil. aetbrito@gmail.com. 3. Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil. 4. Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.
Abstract
BACKGROUND: 68 Ga-PSMA-PET has an increasing importance in the evaluation of prostate cancer patients due to its high sensitivity and specificity in identifying neoplastic lesions in the clinical setting of elevated prostate-specific antigen (PSA). The objective of this study was to calculate the whole-body tumor burden using volumetric quantification of lesions detected in 68Ga-PSMA-PET of prostate cancer patients with biochemical recurrence and correlate these findings with clinical and image parameters. METHODS: Each patient had their 68Ga-PSMA-PET analyzed for the presence of neoplastic lesions. Their PSA levels and clinical information were recorded. In positive cases, the tumor burden (TL-PSMA) was calculated with a semi-automatic software and manually, and the results are analyzed and tested. RESULTS: We analyzed 100 prostate cancer patients, mean age of 69.9 ± 9.7 years and a median PSA of 1.73 ng/dL. 68Ga-PSMA-PET identified neoplastic lesions in 72% of them. The median TL-PSMA was 55.95 ml (1.1-28,080 ml). TL-PSMA and PSA were strongly correlated (rho = 0.71, p < 0.0001, 95% CI 0.60-0.80). TL-PSMA and PSA levels groups had a significant correlation and TL-PSMA and Gleason score were independent variables associated with PSA levels (p < 0.05). CONCLUSION: TL-PSMA strongly and independently correlates with PSA levels in prostate cancer patients and could be used as a biomarker to separate them into groups with high or low tumor burden, instead of considering only the number of lesions.
BACKGROUND: 68 Ga-PSMA-PET has an increasing importance in the evaluation of prostate cancerpatients due to its high sensitivity and specificity in identifying neoplastic lesions in the clinical setting of elevated prostate-specific antigen (PSA). The objective of this study was to calculate the whole-body tumor burden using volumetric quantification of lesions detected in 68Ga-PSMA-PET of prostate cancerpatients with biochemical recurrence and correlate these findings with clinical and image parameters. METHODS: Each patient had their 68Ga-PSMA-PET analyzed for the presence of neoplastic lesions. Their PSA levels and clinical information were recorded. In positive cases, the tumor burden (TL-PSMA) was calculated with a semi-automatic software and manually, and the results are analyzed and tested. RESULTS: We analyzed 100 prostate cancerpatients, mean age of 69.9 ± 9.7 years and a median PSA of 1.73 ng/dL. 68Ga-PSMA-PET identified neoplastic lesions in 72% of them. The median TL-PSMA was 55.95 ml (1.1-28,080 ml). TL-PSMA and PSA were strongly correlated (rho = 0.71, p < 0.0001, 95% CI 0.60-0.80). TL-PSMA and PSA levels groups had a significant correlation and TL-PSMA and Gleason score were independent variables associated with PSA levels (p < 0.05). CONCLUSION: TL-PSMA strongly and independently correlates with PSA levels in prostate cancerpatients and could be used as a biomarker to separate them into groups with high or low tumor burden, instead of considering only the number of lesions.
Authors: Philipp E Hartrampf; Marieke Heinrich; Anna Katharina Seitz; Joachim Brumberg; Ioannis Sokolakis; Charis Kalogirou; Andreas Schirbel; Hubert Kübler; Andreas K Buck; Constantin Lapa; Markus Krebs Journal: J Clin Med Date: 2020-05-08 Impact factor: 4.241