BACKGROUND: To determine the impact of the number of harvested mediastinal lymph nodes (MLNs) and assessed N2 stations on the mediastinal recurrence for pathologic stage I invasive lung adenocarcinoma (IADC). METHODS: A total of 2,048 patients with stage I IADC undergoing surgical resection were enrolled at Shanghai Chest Hospital from 2009 to 2013. Survival analysis was performed by Kaplan-Meier method along with univariable and multivariable cox regression analysis. RESULTS: For patients with ≥5 MLNs, mediastinum-specific relapse-free survival (MS-RFS) rates were 98.3% and 96.6% for 3- and 5-year, respectively, which significantly demonstrated better survival outcomes against those with <5 MLNs (96.3% and 92.8%, respectively, log-rank P=0.018). Additionally, the 3- and 5-year RFS of patients with assessed N2 stations ≥3 (98.2% and 95.8%) were exceptionally better when compared with those with N2 stations <3 (95.5%, 90.3%, log-rank P<0.001). In the univariable and multivariable cox analyses, we found that the number of assessed N2 stations was an independent predictor to MS-RFS (HR =0.468; 95% CI, 0.312-0.867; P=0.020) as opposed to the number of harvested MLNs (HR =0.856; 95% CI, 0.423-1.489; P=0.543) which was not a predictor. CONCLUSIONS: Based on our results, we recommend, for a better MS-RFS among patients with pathological stage I IADC, that the cutoff values for harvested MLNs and assessed N2 stations be 5 and 3, respectively. In addition, the number of assessed N2 stations was still an independent predictor to MS-RFS.
BACKGROUND: To determine the impact of the number of harvested mediastinal lymph nodes (MLNs) and assessed N2 stations on the mediastinal recurrence for pathologic stage I invasive lung adenocarcinoma (IADC). METHODS: A total of 2,048 patients with stage I IADC undergoing surgical resection were enrolled at Shanghai Chest Hospital from 2009 to 2013. Survival analysis was performed by Kaplan-Meier method along with univariable and multivariable cox regression analysis. RESULTS: For patients with ≥5 MLNs, mediastinum-specific relapse-free survival (MS-RFS) rates were 98.3% and 96.6% for 3- and 5-year, respectively, which significantly demonstrated better survival outcomes against those with <5 MLNs (96.3% and 92.8%, respectively, log-rank P=0.018). Additionally, the 3- and 5-year RFS of patients with assessed N2 stations ≥3 (98.2% and 95.8%) were exceptionally better when compared with those with N2 stations <3 (95.5%, 90.3%, log-rank P<0.001). In the univariable and multivariable cox analyses, we found that the number of assessed N2 stations was an independent predictor to MS-RFS (HR =0.468; 95% CI, 0.312-0.867; P=0.020) as opposed to the number of harvested MLNs (HR =0.856; 95% CI, 0.423-1.489; P=0.543) which was not a predictor. CONCLUSIONS: Based on our results, we recommend, for a better MS-RFS among patients with pathological stage I IADC, that the cutoff values for harvested MLNs and assessed N2 stations be 5 and 3, respectively. In addition, the number of assessed N2 stations was still an independent predictor to MS-RFS.
Authors: Chukwumere E Nwogu; Adrienne Groman; Daniel Fahey; Sai Yendamuri; Elisabeth Dexter; Todd L Demmy; Austin Miller; Mary Reid Journal: Ann Thorac Surg Date: 2012-03-20 Impact factor: 4.330
Authors: William D Travis; Elisabeth Brambilla; Masayuki Noguchi; Andrew G Nicholson; Kim R Geisinger; Yasushi Yatabe; David G Beer; Charles A Powell; Gregory J Riely; Paul E Van Schil; Kavita Garg; John H M Austin; Hisao Asamura; Valerie W Rusch; Fred R Hirsch; Giorgio Scagliotti; Tetsuya Mitsudomi; Rudolf M Huber; Yuichi Ishikawa; James Jett; Montserrat Sanchez-Cespedes; Jean-Paul Sculier; Takashi Takahashi; Masahiro Tsuboi; Johan Vansteenkiste; Ignacio Wistuba; Pan-Chyr Yang; Denise Aberle; Christian Brambilla; Douglas Flieder; Wilbur Franklin; Adi Gazdar; Michael Gould; Philip Hasleton; Douglas Henderson; Bruce Johnson; David Johnson; Keith Kerr; Keiko Kuriyama; Jin Soo Lee; Vincent A Miller; Iver Petersen; Victor Roggli; Rafael Rosell; Nagahiro Saijo; Erik Thunnissen; Ming Tsao; David Yankelewitz Journal: J Thorac Oncol Date: 2011-02 Impact factor: 15.609
Authors: Gail E Darling; Mark S Allen; Paul A Decker; Karla Ballman; Richard A Malthaner; Richard I Inculet; David R Jones; Robert J McKenna; Rodney J Landreneau; Valerie W Rusch; Joe B Putnam Journal: J Thorac Cardiovasc Surg Date: 2011-03 Impact factor: 5.209