Literature DB >> 30744422

tRNA modification and cancer: potential for therapeutic prevention and intervention.

Lauren Endres1, Michael Fasullo2, Rebecca Rose3.   

Abstract

Transfer RNAs (tRNAs) undergo extensive chemical modification within cells through the activity of tRNA methyltransferase enzymes (TRMs). Although tRNA modifications are dynamic, how they impact cell behavior after stress and during tumorigenesis is not well understood. This review discusses how tRNA modifications influence the translation of codon-biased transcripts involved in responses to oxidative stress. We further discuss emerging mechanistic details about how aberrant TRM activity in cancer cells can direct programs of codon-biased translation that drive cancer cell phenotypes. The studies reviewed here predict future preventative therapies aimed at augmenting TRM activity in individuals at risk for cancer due to exposure. They further predict that attenuating TRM-dependent translation in cancer cells may limit disease progression while leaving noncancerous cells unharmed.

Entities:  

Keywords:  anticodon; cancer; codon-bias; modification; oxidative stress; tRNA

Mesh：

Substances：

Year:  2019        PMID： 30744422     DOI： 10.4155/fmc-2018-0404

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  9 in total

Review 1.  Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases.

Authors:  Sébastien Bonnet; Olivier Boucherat; Roxane Paulin; Danchen Wu; Charles C T Hindmarch; Stephen L Archer; Rui Song; Joseph B Moore; Steeve Provencher; Lubo Zhang; Shizuka Uchida
Journal:  Am J Physiol Cell Physiol       Date:  2019-09-04       Impact factor: 4.249

Review 2.  tRNA Function and Dysregulation in Cancer.

Authors:  Tania Gupta; Mark G Malkin; Suyun Huang
Journal:  Front Cell Dev Biol       Date:  2022-06-01

3.  An SNP-Based Genetic Map and QTL Mapping for Growth Traits in the Red-Spotted Grouper (Epinephelus akaara).

Authors:  Xiang Wang; Shoujia Jiang; Leyun Zheng; Ling Xiao; Xinhui Zhang; Dengdong Wang; Shuisheng Li; Qiong Shi; Shuiqing Wu; Haoran Lin; Xinxin You; Yong Zhang
Journal:  Genes (Basel)       Date:  2019-10-12       Impact factor: 4.096

Review 4.  Riddle of the Sphinx: Emerging Role of Transfer RNAs in Human Cancer.

Authors:  Zhilin Qiu; Qin Wang; Lei Liu; Guozheng Li; Yi Hao; Shipeng Ning; Lei Zhang; Xin Zhang; Yihai Chen; Jiale Wu; Xinheng Wang; Shuai Yang; Yaoxin Lin; Shouping Xu
Journal:  Front Pharmacol       Date:  2021-12-15       Impact factor: 5.810

Review 5.  Technological Approaches in the Analysis of Extracellular Vesicle Nucleotide Sequences.

Authors:  Tine Tesovnik; Barbara Jenko Bizjan; Robert Šket; Maruša Debeljak; Tadej Battelino; Jernej Kovač
Journal:  Front Bioeng Biotechnol       Date:  2021-12-23

6.  N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.

Authors:  Hui Han; Chunlong Yang; Jieyi Ma; Shuishen Zhang; Siyi Zheng; Rongsong Ling; Kaiyu Sun; Siyao Guo; Boxuan Huang; Yu Liang; Lu Wang; Shuang Chen; Zhaoyu Wang; Wei Wei; Ying Huang; Hao Peng; Yi-Zhou Jiang; Junho Choe; Shuibin Lin
Journal:  Nat Commun       Date:  2022-03-18       Impact factor: 14.919

7.  Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.

Authors:  Wenhao Chen; Yuxiang Lin; Meichen Jiang; Qingshui Wang; Qiang Shu
Journal:  J Transl Med       Date:  2022-08-12       Impact factor: 8.440

8.  METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression.

Authors:  Jieyi Ma; Hui Han; Ying Huang; Chunlong Yang; Siyi Zheng; Tiancai Cai; Jiong Bi; Xiaohui Huang; Ruiming Liu; Libin Huang; Yifeng Luo; Wen Li; Shuibin Lin
Journal:  Mol Ther       Date:  2021-08-08       Impact factor: 11.454

9.  FTSJ1 regulates tRNA 2'-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression.

Authors:  Qihan He; Lin Yang; Kaiping Gao; Peikun Ding; Qianqian Chen; Juan Xiong; Wenhan Yang; Yi Song; Liang Wang; Yejun Wang; Lijuan Ling; Weiming Wu; Jisong Yan; Peng Zou; Yuchen Chen; Rihong Zhai
Journal:  Cell Death Dis       Date:  2020-05-11       Impact factor: 8.469
  9 in total

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