| Literature DB >> 30742906 |
Ammad Ahmad Farooqi1, Enrique Fuentes-Mattei2, Sundas Fayyaz3, Priyank Raj2, Matthew Goblirsch4, Palmiro Poltronieri5, George A Calin6.
Abstract
Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.Entities:
Keywords: Epigenetic regulation; Non-coding RNAs; miRNAs
Mesh:
Substances:
Year: 2019 PMID: 30742906 DOI: 10.1016/j.semcancer.2019.02.003
Source DB: PubMed Journal: Semin Cancer Biol ISSN: 1044-579X Impact factor: 15.707