| Literature DB >> 30740984 |
Angelica Boeve1, Tanis J Ferman2, Jeremiah Aakre1, Erik St Louis1, Michael Silber1, Mary Machulda1, Julie Fields1, Neill Graff-Radford2, Michelle Mielke1, Yonas Geda3, David Jones1, Jonathon Graff-Radford1, David Knopman1, Ronald Petersen1, Brad Boeve1.
Abstract
There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P < .05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P < .01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.Entities:
Keywords: Alzheimer’s disease; dementia with Lewy bodies; excessive daytime sleepiness; frontotemporal dementia
Mesh：
Year: 2019 PMID： 30740984 PMCID： PMC6709580 DOI： 10.1177/1533317519828046
Source DB: PubMed Journal: Am J Alzheimers Dis Other Demen ISSN： 1533-3175 Impact factor: 2.035