Christina Mantzouki1, Despoina Bliatka2, Paschalia K Iliadou2, Alexandra Margeli3, Ioannis Papassotiriou4, George Mastorakos1, Eleni Kousta1, Dimitrios G Goulis2. 1. Research in Female Reproduction Postgraduate Course, National and Kapodistrian University of Athens Medical School, Athens, Greece. 2. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece. 3. Department of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, Greece. 4. Department of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, Greece. Electronic address: ipapassotiriou@gmail.com.
Abstract
BACKGROUND: Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed BPA according to the cause of male infertility. AIM: To investigate serum BPA concentrations in infertile men according to infertility cause. PATIENTS AND METHODS: Men with infertility (n = 55) [non-obstructive azoospermia (n = 23), cryptorchidism (n = 12), varicocele (n = 20)] compared with fertile men (n = 25). Serum BPA concentrations were measured along with clinical and hormonal assessment. RESULTS: BPA was detected in all men, with no difference between infertile and control groups [median (IQR) 0.19 (0.45) vs. 0.18 (0.28) ng/ml, p = 0.689] or among the infertility cause [azoospermia 0.30 (0.69), cryptorchidism 0.12 (0.39), varicocele 0.17 (0.23) ng/ml, p = 0.316]. High concentrations of BPA (>3 ng/ml) were observed only in infertile men. Α negative correlation was observed between ΒΡΑ concentrations and AMH (r = -0.320, p < 0.01). CONCLUSIONS: Although male infertility cannot be attributed to exposure to BPA, high concentrations of BPA could contribute to infertility.
BACKGROUND:Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed BPA according to the cause of male infertility. AIM: To investigate serum BPA concentrations in infertile men according to infertility cause. PATIENTS AND METHODS: Men with infertility (n = 55) [non-obstructive azoospermia (n = 23), cryptorchidism (n = 12), varicocele (n = 20)] compared with fertile men (n = 25). Serum BPA concentrations were measured along with clinical and hormonal assessment. RESULTS:BPA was detected in all men, with no difference between infertile and control groups [median (IQR) 0.19 (0.45) vs. 0.18 (0.28) ng/ml, p = 0.689] or among the infertility cause [azoospermia 0.30 (0.69), cryptorchidism 0.12 (0.39), varicocele 0.17 (0.23) ng/ml, p = 0.316]. High concentrations of BPA (>3 ng/ml) were observed only in infertile men. Α negative correlation was observed between ΒΡΑ concentrations and AMH (r = -0.320, p < 0.01). CONCLUSIONS: Although male infertility cannot be attributed to exposure to BPA, high concentrations of BPA could contribute to infertility.
Authors: Thea Emily Benson; Anne Gaml-Sørensen; Andreas Ernst; Nis Brix; Karin Sørig Hougaard; Katia Keglberg Hærvig; Jens Peter Ellekilde Bonde; Sandra Søgaard Tøttenborg; Christian H Lindh; Cecilia Høst Ramlau-Hansen; Gunnar Toft Journal: Int J Environ Res Public Health Date: 2021-02-11 Impact factor: 3.390